CAJ | 학술논문

蓝细菌是一种能进行光合作用的原核生物，具有非核糖体肽合成酶和聚酮合成酶系统，能够合成复杂多样的次级代谢产物，多数都具有生物活性，如抗癌，抗病毒，抗菌，抗原生虫，抑制蛋白酶活性以及紫外线防护等。这些次级代谢产物化学结构的高度多样性，使蓝细菌成为未来新型药物开发的潜在来源。本文综述了目前蓝细菌次级代谢产物的主要种类和每一类性质的化合物的生物活性作用机理，作用效果以及研究现状。
람세균시일충능진행광합작용적원핵생물，구유비핵당체태합성매화취동합성매계통，능구합성복잡다양적차급대사산물，다수도구유생물활성，여항암，항병독，항균，항원생충，억제단백매활성이급자외선방호등。저사차급대사산물화학결구적고도다양성，사람세균성위미래신형약물개발적잠재래원。본문종술료목전람세균차급대사산물적주요충류화매일류성질적화합물적생물활성작용궤리，작용효과이급연구현상。
Cyanobacteria are a group of photosynthetic prokaryotes with long evolutionary history .They possess non-ribosomal peptide synthetase and polyketide synthetase systems ,which could biosynthesize a variety of complex secondary metabolites .Most of these metabolites showed biological activities including anticancer,antiviral,antibacterial,antiprotozoal,protease inhibition and UV screening activities .The high degree of chemical diversity in these metabolites made cyanobacteria be the potential source for new drug discovery .This paper summarized the the main types of secondary metabolites of cyanobacteria and made a review on the mechanism of action ,effects and research progress .