CAJ | 학술논문

目的：研究乳腺癌CD33＋髓系来源的抑制细胞（ MDSCs）中吲哚胺2，3－双加氧酶（ IDO）表达情况及与Foxp3＋调节性T细胞（Tregs）分布关系和临床意义。方法：运用免疫组化单染技术检测CD33＋MDSCs细胞、Foxp3＋Tregs，采用免疫组化双染检测CD33＋MDSCs细胞中IDO的表达情况。结果：癌组织中CD33＋MDSCs细胞、Foxp3＋Tregs分布无序，呈散在分布；Foxp3＋Tregs高比例组中，CD33＋MD-SCs细胞中IDO呈高表达，差异有统计学意义（ P＜0．05）；CD33＋MDSCs中IDO的表达与患者年龄、肿瘤直径和组织学分级无明显关系，但与是否有淋巴结转移有密切关系（ P＜0．05）。结论：乳腺癌中CD33＋MDSCs中IDO高表达参与肿瘤细胞免疫耐受的形成，可能与乳腺癌淋巴转移存在密切联系。
목적：연구유선암CD33＋수계래원적억제세포（ MDSCs）중신타알2，3－쌍가양매（ IDO）표체정황급여Foxp3＋조절성T세포（Tregs）분포관계화림상의의。방법：운용면역조화단염기술검측CD33＋MDSCs세포、Foxp3＋Tregs，채용면역조화쌍염검측CD33＋MDSCs세포중IDO적표체정황。결과：암조직중CD33＋MDSCs세포、Foxp3＋Tregs분포무서，정산재분포；Foxp3＋Tregs고비례조중，CD33＋MD-SCs세포중IDO정고표체，차이유통계학의의（ P＜0．05）；CD33＋MDSCs중IDO적표체여환자년령、종류직경화조직학분급무명현관계，단여시부유림파결전이유밀절관계（ P＜0．05）。결론：유선암중CD33＋MDSCs중IDO고표체삼여종류세포면역내수적형성，가능여유선암림파전이존재밀절련계。
Objective:To study the expression of indoleamine 2,3-dioxygenase ( IDO) in CD33+mye-loid-derived suppressor cells ( MDSCs) and the relationships between the expression of IDO and Foxp 3+reg-ulatory T cells ( Tregs) distribution and clinical significance. Method:Immunohistochemical single staining technique was used to detect CD33+MDSCs cells and Foxp3+Tregs.The immunohistochemical double staining was used to detect CD33+MDSCs cells indoleamine 2,3-bis dioxygenase (IDO) expression.Result:Carci-noma CD33+MDSCs cells, Foxp3+Tregs distribution were disorder and scattered in carcinoma. It showed sig-nificant difference between the expression of MDSCs IDO and Tregs distribution ( P<0.05). The expression of CD33+MDSCs in IDO had no relation with breast cancer , irrespective of age , tumor size and histological grade were coreelated with whether lymph node metastasis (P<0.05).Conclusion:It showed a close contact between carcinoma CD 33+MDSCs IDO expression in tumor cells and the formation of immune tolerance. Car-cinoma CD33+MDSCs IDO expression may be associated with the presence of lymph node metastasis.