中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2013年
36期
22-23,24
,共3页
甲氨蝶呤%米非司酮%异位妊娠
甲氨蝶呤%米非司酮%異位妊娠
갑안접령%미비사동%이위임신
Methotrexate%Mifepristone%Ectopic pregnancy
目的：探讨两种不同方案的甲氨蝶呤联合米非司酮治疗异位妊娠的临床效果。方法：选取80例异位妊娠患者作研究对象，均为本院妇产科2010年2月-2013年2月收治，随机数字表法分组，0.4 mg/（kg·d）甲氨蝶呤联合米非司酮（A组）与1 mg/kg甲氨蝶呤联合米非司酮（B组）临床效果进行比较。结果：B组选取病例临床总有效率为100%，高于A组97%，两组比较差异无统计学意义（P>0.05）。两组治疗前血β-hCG值比较差异无统计学意义（P>0.05），治疗后第5天、第10天两组均有降低，但B组下降幅度显著高于A组（P<0.05），两组治疗15 d、30 d差异无统计学意义（P>0.05）。B组胃肠道反应率为17.5%，白细胞下降40%，A组分别为80%、82.5%，两组比较差异有统计学意义（P<0.05）。结论：甲氨蝶呤采用1 mg/kg，与米非司酮联合治疗异位妊娠，可保证治疗效果，降低不良事件率，保障用药安全，满足了患者生育要求，具有非常积极的临床意义。
目的：探討兩種不同方案的甲氨蝶呤聯閤米非司酮治療異位妊娠的臨床效果。方法：選取80例異位妊娠患者作研究對象，均為本院婦產科2010年2月-2013年2月收治，隨機數字錶法分組，0.4 mg/（kg·d）甲氨蝶呤聯閤米非司酮（A組）與1 mg/kg甲氨蝶呤聯閤米非司酮（B組）臨床效果進行比較。結果：B組選取病例臨床總有效率為100%，高于A組97%，兩組比較差異無統計學意義（P>0.05）。兩組治療前血β-hCG值比較差異無統計學意義（P>0.05），治療後第5天、第10天兩組均有降低，但B組下降幅度顯著高于A組（P<0.05），兩組治療15 d、30 d差異無統計學意義（P>0.05）。B組胃腸道反應率為17.5%，白細胞下降40%，A組分彆為80%、82.5%，兩組比較差異有統計學意義（P<0.05）。結論：甲氨蝶呤採用1 mg/kg，與米非司酮聯閤治療異位妊娠，可保證治療效果，降低不良事件率，保障用藥安全，滿足瞭患者生育要求，具有非常積極的臨床意義。
목적：탐토량충불동방안적갑안접령연합미비사동치료이위임신적림상효과。방법：선취80례이위임신환자작연구대상，균위본원부산과2010년2월-2013년2월수치，수궤수자표법분조，0.4 mg/（kg·d）갑안접령연합미비사동（A조）여1 mg/kg갑안접령연합미비사동（B조）림상효과진행비교。결과：B조선취병례림상총유효솔위100%，고우A조97%，량조비교차이무통계학의의（P>0.05）。량조치료전혈β-hCG치비교차이무통계학의의（P>0.05），치료후제5천、제10천량조균유강저，단B조하강폭도현저고우A조（P<0.05），량조치료15 d、30 d차이무통계학의의（P>0.05）。B조위장도반응솔위17.5%，백세포하강40%，A조분별위80%、82.5%，량조비교차이유통계학의의（P<0.05）。결론：갑안접령채용1 mg/kg，여미비사동연합치료이위임신，가보증치료효과，강저불량사건솔，보장용약안전，만족료환자생육요구，구유비상적겁적림상의의。
Objective:To discuss the clinical effects of two different schemes of methotrexate combined with mifepristone in the treatment of ectopic pregnancy. Method:80 patients with ectopic pregnancy were selected as the research objects,and all the patients were received in the obstetrics and gynecology of our hospital from February 2010 to February 2013,and they were randomly divided into group A with 0.4 mg/(kg·d)methotrexate combined with mifepristone and group B with 1 mg/kg methotrexate combined with mifepristone,then the clinical effects of the two groups were compared. Result:The total clinical effective rate of group B was 100%,and which was significantly higher than that of group A(97.%),and the difference between the two groups was not statistically significant(P>0.05). There was no significant difference between the values of Blood beta hCG before treatment in the two groups(P>0.05),and which decreased in the two groups after treatment 5 d and 10 d,but group B decreased significantly higher than group A(P<0.05),after treatment 15 d and 30 d,there was no obvious difference(P>0.05). The gastrointestinal response rate of group B was 17.5%,and the drop rate of white blood cells was 40%,and that of group A was 80%and 82.5%respectively,and the differences were statistically significant(P<0.05). Conclusion:The therapy of methotrexate with 1 mg/kg combined with mifepristone in the treatment of ectopic pregnancy can guarantee the therapeutic effect,decrease the rate of adverse events,ensure the safety of drug use,meet the needs of patients with fertility,and has very positive clinical significance.
