CAJ | 학술논문

目的：观察血清降钙素原（ PCT）在抗结核治疗时的动态变化，及早发现耐药患者。方法选择300例初治接受正规抗结核药物治疗的涂阳培阳肺结核患者，治疗前均做罗氏比例法药敏试验和血清 PCT检测，并于抗结核治疗期间每个月做血清PCT检测，分析结核分枝杆菌耐药和敏感患者PCT动态变化规律，以便及早发现耐药患者。结果耐药组和敏感组肺结核患者治疗前血清PCT差异无统计学意义（ P>0.05），治疗后1个月、2个月时2组血清PCT均降低，但组间差异无统计学意义（ P>0.05），治疗3、4和6个月时耐药组无下降，与敏感组相比差异显著（P<0.01）。结论血清PCT可作为肺结核患者抗结核治疗疗效评估指标，并对耐药结核有预测作用。
목적：관찰혈청강개소원（ PCT）재항결핵치료시적동태변화，급조발현내약환자。방법선택300례초치접수정규항결핵약물치료적도양배양폐결핵환자，치료전균주라씨비례법약민시험화혈청 PCT검측，병우항결핵치료기간매개월주혈청PCT검측，분석결핵분지간균내약화민감환자PCT동태변화규률，이편급조발현내약환자。결과내약조화민감조폐결핵환자치료전혈청PCT차이무통계학의의（ P>0.05），치료후1개월、2개월시2조혈청PCT균강저，단조간차이무통계학의의（ P>0.05），치료3、4화6개월시내약조무하강，여민감조상비차이현저（P<0.01）。결론혈청PCT가작위폐결핵환자항결핵치료료효평고지표，병대내약결핵유예측작용。
Objective To observe the dynamic changes of serum procalcitonin( PCT)in anti tuberculosis treatment, in order to find resistant patients early. Methods 300 cases initial treatment pulmonary tuberculosis patients with smear and culture positive accepting regular anti tuberculosis drug combination were chosed. LowenStein-Jensen( L-J)culture proportion method of drug sensitivity test and serum PCT were detected before treatment. And during the period of anti tuberculosis treat-ment,serum PCT was detected every month. The dynamic changes of PCT in mycobacterium tuberculosis drug resistance and sensitive patients were analyzed,in order to early detect resistant patients. Results The serum PCT had no significant differ-ence between the resistant group and sensitive group of pulmonary tuberculosis patients before treatment(P >0. 05). After treatment for 1 months and 2 months,the serum PCT of both groups decreased,but there was no significant difference between the 2 groups(P>0. 05). After treatment for 3,4 and 6 months,the resistance group no longer decreased,and there was signifi-cant difference compared with sensitive group(P<0. 01). Conclusion The serum PCT can be used as the curative effect e-valuation index of anti tuberculosis treatment in patients with pulmonary tuberculosis,and has prediction effect on drug resistant tuberculosis.