东南大学学报（医学版）
東南大學學報（醫學版）
동남대학학보（의학판）
JOURNAL OF SOUTHEAST UNIVERSITY(MEDICAL SCIENCE EDITION)
2014年
2期
121-125
,共5页
王艳萍%余江毅%殷汉%安晓飞%王晓来%王尧%孙子林
王豔萍%餘江毅%慇漢%安曉飛%王曉來%王堯%孫子林
왕염평%여강의%은한%안효비%왕효래%왕요%손자림
2型糖尿病%糖尿病慢性并发症%六味地黄丸%银杏叶片%趋化因子
2型糖尿病%糖尿病慢性併髮癥%六味地黃汍%銀杏葉片%趨化因子
2형당뇨병%당뇨병만성병발증%륙미지황환%은행협편%추화인자
T2DM%diabetic chronic complications%Liuwei Dihuang%Ginkgo Leaf%fractalkine
目的：通过随机对照试验（ RCT ）观察六味地黄丸联合银杏叶片对2型糖尿病患者趋化因子fractalkine的影响。方法：将116例2型糖尿病患者随机分为中药组与对照组，各58例。中药组加用六味地黄丸和银杏叶片，对照组加用安慰剂。连续观察24个月。结果：（1）干预24个月后，中药组肾小球清除率（GFR）呈上升趋势，颈动脉内膜中膜厚度（IMT）呈下降趋势。（2）尿微量白蛋白/肌酐之值（ACR）与中药干预、GFR、血脂、fractalkine、CRP有明显相关性，IMT与年龄、病程、CRP呈正相关（ P＜0.05）。回归分析显示，中药干预为糖尿病慢性并发症的保护性因素，fractalkine、CRP为其危险因素。（3）干预24个月后，中药组血清fractalkine由0.66（0.32，0.79）ng· ml -1下降至0.55（0.35，0.69）ng· ml -1（P＜0.05）。结论：CRP、fractalkine为糖尿病慢性并发症的危险因素，六味地黄丸联合银杏叶片可有效减少fractalkine的释放，调节炎症通路，有效防治糖尿病慢性并发症。
目的：通過隨機對照試驗（ RCT ）觀察六味地黃汍聯閤銀杏葉片對2型糖尿病患者趨化因子fractalkine的影響。方法：將116例2型糖尿病患者隨機分為中藥組與對照組，各58例。中藥組加用六味地黃汍和銀杏葉片，對照組加用安慰劑。連續觀察24箇月。結果：（1）榦預24箇月後，中藥組腎小毬清除率（GFR）呈上升趨勢，頸動脈內膜中膜厚度（IMT）呈下降趨勢。（2）尿微量白蛋白/肌酐之值（ACR）與中藥榦預、GFR、血脂、fractalkine、CRP有明顯相關性，IMT與年齡、病程、CRP呈正相關（ P＜0.05）。迴歸分析顯示，中藥榦預為糖尿病慢性併髮癥的保護性因素，fractalkine、CRP為其危險因素。（3）榦預24箇月後，中藥組血清fractalkine由0.66（0.32，0.79）ng· ml -1下降至0.55（0.35，0.69）ng· ml -1（P＜0.05）。結論：CRP、fractalkine為糖尿病慢性併髮癥的危險因素，六味地黃汍聯閤銀杏葉片可有效減少fractalkine的釋放，調節炎癥通路，有效防治糖尿病慢性併髮癥。
목적：통과수궤대조시험（ RCT ）관찰륙미지황환연합은행협편대2형당뇨병환자추화인자fractalkine적영향。방법：장116례2형당뇨병환자수궤분위중약조여대조조，각58례。중약조가용륙미지황환화은행협편，대조조가용안위제。련속관찰24개월。결과：（1）간예24개월후，중약조신소구청제솔（GFR）정상승추세，경동맥내막중막후도（IMT）정하강추세。（2）뇨미량백단백/기항지치（ACR）여중약간예、GFR、혈지、fractalkine、CRP유명현상관성，IMT여년령、병정、CRP정정상관（ P＜0.05）。회귀분석현시，중약간예위당뇨병만성병발증적보호성인소，fractalkine、CRP위기위험인소。（3）간예24개월후，중약조혈청fractalkine유0.66（0.32，0.79）ng· ml -1하강지0.55（0.35，0.69）ng· ml -1（P＜0.05）。결론：CRP、fractalkine위당뇨병만성병발증적위험인소，륙미지황환연합은행협편가유효감소fractalkine적석방，조절염증통로，유효방치당뇨병만성병발증。
Objective:To investigate the effect of combination therapy with Liuwei Dihuang plus Ginkgo Leaf on fractalkine in type 2 diabetic patients through RCT .Method:116 patients were randomly divided into treatment group(n=58) and control group(n=58), and treated with Liuwei Dihuang combined with Ginkgo Leaf or placebo respectively, and follow up with 24 months.Results:(1) After 24 months treatment, GFR of patients in treatment group showed an increasing tendency .IMT of patients in treatment group showed a decreasing tendency .(2) There was significant correlation between ACR and blood lipid , GFR, CRP, fractalkine, combination therapy with Liuwei Dihuang plus Ginkgo Leaf .There was also significant correlation between IMT and age , duration of T2DM, CRP. The regression analysis showed combination therapy with Liuwei Dihuang plus Ginkgo Leaf was the protective factor of diabetic chronic complications , fractalkine and CRP were the risk factors .(3) The level of fractalkine in those who took Liuwei Dihuang combined with Ginkgo Leaf decreased from 0.66(0.32,0.79)ng· ml-1 to 0.55(0.35, 0.69)ng· ml -1(P<0.05).Conclusion:Cytokines such as CRP and fractalkine were the risk factors of diabetic chronic complications .Combination therapy of Liuwei Dihuang and Ginkgo Leaf has efficacious treatment effect on diabetic chronic complications through inhibiting the release of inflammatory cytokine .
