中国实验方剂学杂志
中國實驗方劑學雜誌
중국실험방제학잡지
CHINESE JOURNAL OF EXPERIMENTAL TRADITIONAL MEDICAL FORMULAE
2013年
18期
90-95
,共6页
陈琳%穆淑珍%晏晨%黄烈军%郝小江
陳琳%穆淑珍%晏晨%黃烈軍%郝小江
진림%목숙진%안신%황렬군%학소강
川楝子%化学成分%分析纯化%结构鉴定
川楝子%化學成分%分析純化%結構鑒定
천련자%화학성분%분석순화%결구감정
fructus Melia toosendan%chemical constituents%separation and purification%structural identification
目的:研究黔产川楝子中的化学成分.方法:应用正、反相硅胶(RP-18型)柱层析；葡聚糖凝胶(Sephadex LH-20型)柱层析,结合重结晶方法进行分离纯化,运用1 H-NMR,13 C-NMR,ESI-MS和ES-MS等现代波谱技术对化合物的结构进行鉴定.结果:从黔产川楝子乙醇提取物中分离鉴定了12个化合物,分别被鉴定为:1-O-tigloyl-1-O-debenzoylohchinal(1),印楝醛(ohchinal,2),1-cinnamoyhrichilinin (3),3,7-diacetyl-14,15-deoxyhavanensin(4),7-O-acetyl-14,15-deoxyhavanensin(5),6α-O-acetyl-7-deacetylnimocinol (6),6α-hydroxyazadirone (7),24-Nor-5(ょ)-13α,17α-chola-14,20,22-triene-3β,7α-diol-21,23-epoxy-4,4,8-trimethyl-3-acetate(8),hedyotol-A(9),2,6-bis (3-methoxy-4-hydroxyphenyl)-3,7-dioxabicyclo[3,3,0]octan-8-one(10),exo-endo-2,6-bis (4'-hydroxy-3 '-methoxy-phenyl)-3,7-dioxabicyclo[3,3,0]octane (11)和betulafolienediolone (12).结论:化合物2～12均为首次从该植物中分离得到.
目的:研究黔產川楝子中的化學成分.方法:應用正、反相硅膠(RP-18型)柱層析；葡聚糖凝膠(Sephadex LH-20型)柱層析,結閤重結晶方法進行分離純化,運用1 H-NMR,13 C-NMR,ESI-MS和ES-MS等現代波譜技術對化閤物的結構進行鑒定.結果:從黔產川楝子乙醇提取物中分離鑒定瞭12箇化閤物,分彆被鑒定為:1-O-tigloyl-1-O-debenzoylohchinal(1),印楝醛(ohchinal,2),1-cinnamoyhrichilinin (3),3,7-diacetyl-14,15-deoxyhavanensin(4),7-O-acetyl-14,15-deoxyhavanensin(5),6α-O-acetyl-7-deacetylnimocinol (6),6α-hydroxyazadirone (7),24-Nor-5(ょ)-13α,17α-chola-14,20,22-triene-3β,7α-diol-21,23-epoxy-4,4,8-trimethyl-3-acetate(8),hedyotol-A(9),2,6-bis (3-methoxy-4-hydroxyphenyl)-3,7-dioxabicyclo[3,3,0]octan-8-one(10),exo-endo-2,6-bis (4'-hydroxy-3 '-methoxy-phenyl)-3,7-dioxabicyclo[3,3,0]octane (11)和betulafolienediolone (12).結論:化閤物2～12均為首次從該植物中分離得到.
목적:연구검산천련자중적화학성분.방법:응용정、반상규효(RP-18형)주층석；포취당응효(Sephadex LH-20형)주층석,결합중결정방법진행분리순화,운용1 H-NMR,13 C-NMR,ESI-MS화ES-MS등현대파보기술대화합물적결구진행감정.결과:종검산천련자을순제취물중분리감정료12개화합물,분별피감정위:1-O-tigloyl-1-O-debenzoylohchinal(1),인련철(ohchinal,2),1-cinnamoyhrichilinin (3),3,7-diacetyl-14,15-deoxyhavanensin(4),7-O-acetyl-14,15-deoxyhavanensin(5),6α-O-acetyl-7-deacetylnimocinol (6),6α-hydroxyazadirone (7),24-Nor-5(ょ)-13α,17α-chola-14,20,22-triene-3β,7α-diol-21,23-epoxy-4,4,8-trimethyl-3-acetate(8),hedyotol-A(9),2,6-bis (3-methoxy-4-hydroxyphenyl)-3,7-dioxabicyclo[3,3,0]octan-8-one(10),exo-endo-2,6-bis (4'-hydroxy-3 '-methoxy-phenyl)-3,7-dioxabicyclo[3,3,0]octane (11)화betulafolienediolone (12).결론:화합물2～12균위수차종해식물중분리득도.
