中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2014年
2期
179-182
,共4页
前列腺增生%白蛋白尿
前列腺增生%白蛋白尿
전렬선증생%백단백뇨
Prostatic hyperplasia%Albuminuria
目的 探讨良性前列腺增生(BPH)与尿白蛋白排泄量的关系. 方法 入选60～70岁的男性住院患者258例,询问病史,根据超声测定的前列腺体积(PV)分为BPH组(PV≥20 ml)和非良性前列腺增生(NBPH)组(PV＜20 ml),检测两组患者尿白蛋白及尿肌酐,并计算尿白蛋白/肌酐(UACR)；检测空腹血糖及空腹胰岛素,计算胰岛素抵抗指数(HOMA-IR).采用Pearson相关分析PV与其他指标的相关性,采用多因素Logistic回归分析患BPH的相关因素. 结果 BPH组的UACR高于NBPH组[(163.6±69.8) mg/g比(73.3±55.6) mg/g,t=4.81,P＜0.01],BPH组较NBPH组的高血压病程长[(9.2±6.6)年比(6.0±3.6)年,t=2.27,P＜0.05].随着尿白蛋白排泄量的增加,BPH的患病率增加(x2=4.58,P＜0.05),PV增大(F=4.85,P＜0.01).Pearson相关分析结果显示,PV与UACR、HOMA-IR、高血压病程、体质指数呈正相关(r=0.248、0.229、0.183、0.157,均P＜0.05).多因素Logistic回归分析显示UACR、HOMA-IR、高血压病程是影响BPH患病的相关因素(OR=16.348、1.040、0.166,均P＜0.05). 结论 BPH与UACR存在相关性,提示动脉粥样硬化与BPH存在密切关系,胰岛素抵抗可能在两者的发生发展中起着重要的作用.
目的 探討良性前列腺增生(BPH)與尿白蛋白排洩量的關繫. 方法 入選60～70歲的男性住院患者258例,詢問病史,根據超聲測定的前列腺體積(PV)分為BPH組(PV≥20 ml)和非良性前列腺增生(NBPH)組(PV＜20 ml),檢測兩組患者尿白蛋白及尿肌酐,併計算尿白蛋白/肌酐(UACR)；檢測空腹血糖及空腹胰島素,計算胰島素牴抗指數(HOMA-IR).採用Pearson相關分析PV與其他指標的相關性,採用多因素Logistic迴歸分析患BPH的相關因素. 結果 BPH組的UACR高于NBPH組[(163.6±69.8) mg/g比(73.3±55.6) mg/g,t=4.81,P＜0.01],BPH組較NBPH組的高血壓病程長[(9.2±6.6)年比(6.0±3.6)年,t=2.27,P＜0.05].隨著尿白蛋白排洩量的增加,BPH的患病率增加(x2=4.58,P＜0.05),PV增大(F=4.85,P＜0.01).Pearson相關分析結果顯示,PV與UACR、HOMA-IR、高血壓病程、體質指數呈正相關(r=0.248、0.229、0.183、0.157,均P＜0.05).多因素Logistic迴歸分析顯示UACR、HOMA-IR、高血壓病程是影響BPH患病的相關因素(OR=16.348、1.040、0.166,均P＜0.05). 結論 BPH與UACR存在相關性,提示動脈粥樣硬化與BPH存在密切關繫,胰島素牴抗可能在兩者的髮生髮展中起著重要的作用.
목적 탐토량성전렬선증생(BPH)여뇨백단백배설량적관계. 방법 입선60～70세적남성주원환자258례,순문병사,근거초성측정적전렬선체적(PV)분위BPH조(PV≥20 ml)화비량성전렬선증생(NBPH)조(PV＜20 ml),검측량조환자뇨백단백급뇨기항,병계산뇨백단백/기항(UACR)；검측공복혈당급공복이도소,계산이도소저항지수(HOMA-IR).채용Pearson상관분석PV여기타지표적상관성,채용다인소Logistic회귀분석환BPH적상관인소. 결과 BPH조적UACR고우NBPH조[(163.6±69.8) mg/g비(73.3±55.6) mg/g,t=4.81,P＜0.01],BPH조교NBPH조적고혈압병정장[(9.2±6.6)년비(6.0±3.6)년,t=2.27,P＜0.05].수착뇨백단백배설량적증가,BPH적환병솔증가(x2=4.58,P＜0.05),PV증대(F=4.85,P＜0.01).Pearson상관분석결과현시,PV여UACR、HOMA-IR、고혈압병정、체질지수정정상관(r=0.248、0.229、0.183、0.157,균P＜0.05).다인소Logistic회귀분석현시UACR、HOMA-IR、고혈압병정시영향BPH환병적상관인소(OR=16.348、1.040、0.166,균P＜0.05). 결론 BPH여UACR존재상관성,제시동맥죽양경화여BPH존재밀절관계,이도소저항가능재량자적발생발전중기착중요적작용.
Objective To investigate the relationship between benign prostatic hyperplasia (BPH) and urine albumin excretion.Methods A total of 258 male inpatients aged 60 to 70 years were enrolled in this study.According to prostate volume (PV) measured by transrectal ultrasonography,patients were divided into BPH group(PV≥20 ml) and NBPH(non benign prostatic hyperplasia) group(PV＜20 ml).Urine albumin and urine creatinine concentrations were measured and urine albumin/creatinine ratio(UACR) was calculated.Fasting blood glucose(FBG) and fasting insulin(FINS) also were measured,insulin resistance index(HOMA-IR) was calculated based on the formula HOMA-IR=ln(FBG × FINS/22.5).The correlation between PV and other indicators were analyzed by Pearson correlation analysis.The risk factors for BPH were analyzed by logistic regression analysis.Results UACR was significantly higher in BPH group than in NBPH group[(163.6± 69.8) mg/g vs.(73.3 ± 55.6) mg/g,t =4.81,P＜ 0.01],and hypertension duration was longer in BPH group than in NBPH group [(9.2±6.6)years vs.(6.0±3.6)years,t=2.27,P＜0.05].The prevalence rate of BPH and PV were increased along with increasing of urine albumin excretion(x2=4.58,F=4.85,respectively,P＜0.05 or 0.01).Prostate volume was positively correlated with UACR,HOMA-IR,hypertension duration,body mass index(r=0.248,0.229,0.183,0.157,respectively,all P ＜ 0.05).Logistic regression analysis indicated that UACR,HOMA-IR and hypertension duration were the risk factors for BPH(OR=16.348,1.040,0.166,respectively,all P ＜0.05).Conclusions BPH is correlated with UACR,which indicates that there is a close relationship between atherosclerosis and BPH.Insulin resistance probably plays an important role in the progression of arteriosclerosis and BPH.
