CAJ | 학술논문

目的：观察氨氯地平联合缬沙坦对老年高血压患者内皮素-1（ET-1）、一氧化氮（NO）及血管弹性功能的影响。方法老年高血压患者40例随机分为2组，每组20例。观察组给予氨氯地平与缬沙坦联合治疗，对照组仅给予缬沙坦治疗，比较2组血压、ET-1、NO以及血管弹性功能指标变化。结果2组治疗2、4、6、8周后，血压均较治疗前下降，且观察组下降较对照组更明显（ P均＜0趑．05）；与治疗前比较，2组治疗8周后ET-1、NO均改善（ P ＜0．05），且观察组改善较对照组明显（ P ＜0．05）；2组治疗8周后，大动脉弹性指数（C1）、小动脉弹性指数（C2）均较治疗前增高，且观察组较对照组增高明显（ P ＜0．05）；治疗8周后，2组脉搏波传导速度（ PWV）及踝臂指数均优于治疗前，且观察组优于对照组（ P ＜0．05）。2组不良反应发生率比较差异无统计学意义（ P ＞0．05）。结论氨氯地平联合缬沙坦治疗老年高血压患者降压效果明显，ET-1均明显下降，NO明显升高，血管弹性功能改善。
목적：관찰안록지평연합힐사탄대노년고혈압환자내피소-1（ET-1）、일양화담（NO）급혈관탄성공능적영향。방법노년고혈압환자40례수궤분위2조，매조20례。관찰조급여안록지평여힐사탄연합치료，대조조부급여힐사탄치료，비교2조혈압、ET-1、NO이급혈관탄성공능지표변화。결과2조치료2、4、6、8주후，혈압균교치료전하강，차관찰조하강교대조조경명현（ P균＜0자．05）；여치료전비교，2조치료8주후ET-1、NO균개선（ P ＜0．05），차관찰조개선교대조조명현（ P ＜0．05）；2조치료8주후，대동맥탄성지수（C1）、소동맥탄성지수（C2）균교치료전증고，차관찰조교대조조증고명현（ P ＜0．05）；치료8주후，2조맥박파전도속도（ PWV）급과비지수균우우치료전，차관찰조우우대조조（ P ＜0．05）。2조불량반응발생솔비교차이무통계학의의（ P ＞0．05）。결론안록지평연합힐사탄치료노년고혈압환자강압효과명현，ET-1균명현하강，NO명현승고，혈관탄성공능개선。
Objective To observe the effect of amlodipine combined with valsartan on the blood pressure ,endothelin (ET-1) and NO in elderly patients with hypertension .Methods Forty cases of elderly patients with hypertension were ran-domly divided into two groups of 20 cases in each group .Observation group were given amlodipine and valsartan combination therapy, the control group only received valsartan , compared two groups'blood pressure,ET-1,NO and vascular elasticity in-dex changes.Results Two groups 2,4,6,8 weeks after treatment, compared with pre-treatment, blood pressure were dropped, and the observation group decreased more significantly than in the control group ( P <0.05);compared with before treatment, 2 groups after 8 weeks of treatment, ET-1, NO were improved ( P <0.05),and observation group significantly im-proved compared with the control group ( P <0.05);in both groups after 8 weeks of treatment,arterial elastic index(C1,C2) increased than those before treatment , and observation group significantly higher than the control group ( P <0.05);after 8 weeks of treatment, in two groups pulse ware velocity(PWV) and ankle -brachial index were better than those pre-treatment, observation group was better than control group ( P <0.05).2 groups'incidence of adverse reactions was showed no signifi-cant difference ( P >0.05).Conclusion It's demonstrated that the amlodipine combined with valsartan had good efficacy in elderly hypertensive patients the antihypertensive effect is obvious ,ET-1 were significantly decreased ,NO were significantly in-creased,vascular elastic function were improved .