CAJ | 학술논문

目的固定剂量复合剂(FDC)与板式组合药在肺结核患者发生中断治疗原因的回顾性调查.方法 2010年1月至10月湛江市结核病防治所登记的225例初治肺结核病患者,1月至5月的85例为对照组,6月至10月的140例为研究组,对患者治疗过程中断治疗发生原因(漏服、服药困难、药物不良反应)进行对比分析.结果研究组化疗过程中的肺结核患者发生过中断治疗20例(14.29％)、对照组25例(29.41％),两组发生中断治疗比较差异有统计学意义(P＜0.05).结论肺结核患者采用固定剂量复合剂化疗,患者依从性较好,化疗过程较板式组合药中断治疗发生率低,可在临床继续推广使用.
목적 고정제량복합제(FDC)여판식조합약재폐결핵환자발생중단치료원인적회고성조사.방법 2010년1월지10월담강시결핵병방치소등기적225례초치폐결핵병환자,1월지5월적85례위대조조,6월지10월적140례위연구조,대환자치료과정중단치료발생원인(루복、복약곤난、약물불량반응)진행대비분석.결과 연구조화료과정중적폐결핵환자발생과중단치료20례(14.29％)、대조조25례(29.41％),량조발생중단치료비교차이유통계학의의(P＜0.05).결론 폐결핵환자채용고정제량복합제화료,환자의종성교호,화료과정교판식조합약중단치료발생솔저,가재림상계속추엄사용.
Objective To survey the reasons of tuberculosis patients discontinuing taking fixed-dose combinations (FDC) and combination plate drugs.Methods January to October in 2010,225 tuberculosis patients primarily cured registered at Tuberculosis Prevention and Control Institution of Zhanjiang.140 cases registering from May and October were set as a study group,and the rest 85 cases as a control group.The reasons (miss taking medicine,difficulties of taking medicine,adverse drug reactions) causing tuberculosis patients discontinuing their therapy were compared and analyzed.Result 20 cases (14.29％) discontinued the treatment in the study group,and 25 cases (29.41％) in the control group,with a statistical difference (P ＜ 0.05).Conclusions Patients taking fixed-dose compound chemotherapy have better treatment compliance than ones taking combination plate drugs.It is worth being clinically generalized.