东南国防医药
東南國防醫藥
동남국방의약
JOURNAL OF SOUTHEAST CHINA NATIONAL DEFENCE MEDICAL SCIENCE
2014年
2期
166-167,206
,共3页
黎茂尧%梁芳%朱军艺%毛冰凌
黎茂堯%樑芳%硃軍藝%毛冰凌
려무요%량방%주군예%모빙릉
假性甲状旁腺功能减退症%临床症状%误诊分析
假性甲狀徬腺功能減退癥%臨床癥狀%誤診分析
가성갑상방선공능감퇴증%림상증상%오진분석
pseudo hypoparathyroidism%clinical symptoms%misdiagnosis analysis
目的:研究并探讨假性甲状旁腺功能减退症的临床特点、诊断及临床治疗情况。方法对2002年3月-2012年3月12例假性甲状旁腺功能减退症( PHP)的临床诊治资料进行回顾分析。结果本组患者男女比例为1∶2,发病年龄(22.5±8.6)岁;所有患者的血钙、尿钙、血镁以及尿磷比正常人低,甲状旁腺素( PTH)、血磷、骨碱性磷酸酶( BALP)比正常人高;较为常见的临床症状为手足抽搐10例、癫痫样发作7例、肢端麻木5例;3例合并遗传性骨营养不良;2例合并甲状腺功能减退;所有患者均行颅脑CT检查,其中10例发现颅内钙化;病症误诊5例,主要误诊为缺钙、原发性癫痫及脑膜炎后遗症。结论假性甲状旁腺功能减退症发病患者多为儿童,临床诊断易被误诊为原发性癫痫。为了降低临床误诊率,临床医生应该注意低钙血症的临床表现。假性甲状旁腺功能减退症主要采用钙剂联合维生素D或是其衍生物进行治疗。对于同时合并甲状腺功能减退的患者应同时给予相应治疗。
目的:研究併探討假性甲狀徬腺功能減退癥的臨床特點、診斷及臨床治療情況。方法對2002年3月-2012年3月12例假性甲狀徬腺功能減退癥( PHP)的臨床診治資料進行迴顧分析。結果本組患者男女比例為1∶2,髮病年齡(22.5±8.6)歲;所有患者的血鈣、尿鈣、血鎂以及尿燐比正常人低,甲狀徬腺素( PTH)、血燐、骨堿性燐痠酶( BALP)比正常人高;較為常見的臨床癥狀為手足抽搐10例、癲癇樣髮作7例、肢耑痳木5例;3例閤併遺傳性骨營養不良;2例閤併甲狀腺功能減退;所有患者均行顱腦CT檢查,其中10例髮現顱內鈣化;病癥誤診5例,主要誤診為缺鈣、原髮性癲癇及腦膜炎後遺癥。結論假性甲狀徬腺功能減退癥髮病患者多為兒童,臨床診斷易被誤診為原髮性癲癇。為瞭降低臨床誤診率,臨床醫生應該註意低鈣血癥的臨床錶現。假性甲狀徬腺功能減退癥主要採用鈣劑聯閤維生素D或是其衍生物進行治療。對于同時閤併甲狀腺功能減退的患者應同時給予相應治療。
목적:연구병탐토가성갑상방선공능감퇴증적림상특점、진단급림상치료정황。방법대2002년3월-2012년3월12례가성갑상방선공능감퇴증( PHP)적림상진치자료진행회고분석。결과본조환자남녀비례위1∶2,발병년령(22.5±8.6)세;소유환자적혈개、뇨개、혈미이급뇨린비정상인저,갑상방선소( PTH)、혈린、골감성린산매( BALP)비정상인고;교위상견적림상증상위수족추휵10례、전간양발작7례、지단마목5례;3례합병유전성골영양불량;2례합병갑상선공능감퇴;소유환자균행로뇌CT검사,기중10례발현로내개화;병증오진5례,주요오진위결개、원발성전간급뇌막염후유증。결론가성갑상방선공능감퇴증발병환자다위인동,림상진단역피오진위원발성전간。위료강저림상오진솔,림상의생응해주의저개혈증적림상표현。가성갑상방선공능감퇴증주요채용개제연합유생소D혹시기연생물진행치료。대우동시합병갑상선공능감퇴적환자응동시급여상응치료。
Objective To investigate the clinical characteristics ,diagnosis and clinical treatment of pseudo hypoparathyroid-ism.Methods 12 cases with pseudo hypoparathyroidism in our hospital from March 2002 to March 2012 were retrospectively ana-lyzed.Results The male/female ratio was 1∶2,and the average age was (22.5 ±8.6) years in 12 cases.The urinary calcium,urinary calcium and blood magnesium phosphate levels in patients was lower than that of healthy people .PTH, phosphorus , BALP level were higher than that of healthy people .The mainly clinical symptoms were tetany (10 cases),epileptic seizures (7 cases),limb numbness (5 cases).3 cases were combined with hereditary osteodystrophy .2 cases were combined with thyroid dysfunction .All patients were de-tected by brain CT examination ,and 10 cases were detected with intracranial calcifications .5 cases were misdiagnosed ,mainly misdiag-nosed as calcium deficiency ,idiopathic epilepsy and meningitis sequelae .Conclusion The pseudo hypoparathyroidism patients were mostly children ,which was easily misdiagnosed as epilepsy .To reduce the misdiagnosis rate ,clinical manifestations should be paid more attention.Pseudo hypoparathyroidism could be effective treated by calcium combined with vitamin D or its derivatives .For patients with concomitant hypothyroidism should be given appropriate treatment .