当代医学
噹代醫學
당대의학
CHINA CONTEMPORARY MEDICINE
2013年
29期
85-86
,共2页
彭东旭%方晓娟%杜均详%梁翠微
彭東旭%方曉娟%杜均詳%樑翠微
팽동욱%방효연%두균상%량취미
肿瘤标志物%乳腺肿瘤%检测
腫瘤標誌物%乳腺腫瘤%檢測
종류표지물%유선종류%검측
Tumor marker%Tumor of breast%Test
目的：探讨肿瘤标志物CA 153、CAl 25、CAl 99、CEA检测对乳腺肿瘤的诊断价值。方法对65例乳腺恶性肿瘤患者、72例乳腺良性肿瘤患者和70例健康志愿者测定血清中CA 153、CAl 25、CAl 99、CEA的含量，用统计学方法分析各组含量差异，比较4种肿瘤标志物单项检测和不同组合联合检测对乳腺恶性肿瘤诊断的灵敏度、特异度和准确度。结果在肿瘤标志物含量及阳性率方面，恶性肿瘤组分别与良性肿瘤组和对照组比较，差异均有统计学意义（P<0.05），良性肿瘤组和对照组比较，差异无统计学意义（P>0.05）。4种肿瘤标志物联合检测分别与其它不同组合的联合检测和单项检测方面比较，其灵敏度、特异性和准确性是最高的，差异有统计学意义（P<0.05）。结论 CA 153、CAl 25、CAl 99、CEA 4项肿瘤标志物联合检测能够对乳腺恶性肿瘤早期诊断和乳腺良恶性肿瘤的鉴别诊断提供重要的依据。
目的：探討腫瘤標誌物CA 153、CAl 25、CAl 99、CEA檢測對乳腺腫瘤的診斷價值。方法對65例乳腺噁性腫瘤患者、72例乳腺良性腫瘤患者和70例健康誌願者測定血清中CA 153、CAl 25、CAl 99、CEA的含量，用統計學方法分析各組含量差異，比較4種腫瘤標誌物單項檢測和不同組閤聯閤檢測對乳腺噁性腫瘤診斷的靈敏度、特異度和準確度。結果在腫瘤標誌物含量及暘性率方麵，噁性腫瘤組分彆與良性腫瘤組和對照組比較，差異均有統計學意義（P<0.05），良性腫瘤組和對照組比較，差異無統計學意義（P>0.05）。4種腫瘤標誌物聯閤檢測分彆與其它不同組閤的聯閤檢測和單項檢測方麵比較，其靈敏度、特異性和準確性是最高的，差異有統計學意義（P<0.05）。結論 CA 153、CAl 25、CAl 99、CEA 4項腫瘤標誌物聯閤檢測能夠對乳腺噁性腫瘤早期診斷和乳腺良噁性腫瘤的鑒彆診斷提供重要的依據。
목적：탐토종류표지물CA 153、CAl 25、CAl 99、CEA검측대유선종류적진단개치。방법대65례유선악성종류환자、72례유선량성종류환자화70례건강지원자측정혈청중CA 153、CAl 25、CAl 99、CEA적함량，용통계학방법분석각조함량차이，비교4충종류표지물단항검측화불동조합연합검측대유선악성종류진단적령민도、특이도화준학도。결과재종류표지물함량급양성솔방면，악성종류조분별여량성종류조화대조조비교，차이균유통계학의의（P<0.05），량성종류조화대조조비교，차이무통계학의의（P>0.05）。4충종류표지물연합검측분별여기타불동조합적연합검측화단항검측방면비교，기령민도、특이성화준학성시최고적，차이유통계학의의（P<0.05）。결론 CA 153、CAl 25、CAl 99、CEA 4항종류표지물연합검측능구대유선악성종류조기진단화유선량악성종류적감별진단제공중요적의거。
Objective To investigate the diagnostic value of tumor marker CA 153、CAl 25、CAl 99、CEA detection in breast cancer. Methods The content of CA 153、CAl 25、CAl 99、CEA in blood serum of 65 patients with breast malignant tumor,72 patients with breast benign tumor and 70 healthy volunteers was determined, the different content in each group was analysed with statistical method, compared the sensitivity, speciifcity and accuracy of four kinds of tumor marker’s single detection and joint detection in different groups. Results Tumor with that in the control group of benign tumor, the differ Compared the content of tumor marker and the positive rate in the group of malignant, the difference was statistical signiifcance(P<0.05), compared the group of benign tumor with the control group, the difference was no statistical signiifcance(P>0.05). Compared the joint detection with the other various combination’s joint detection and single detection of four kinds of tumors separately, the sensitivity, speciifcity and accuracy were the highest, the difference was statistical signiifcance(P<0.05). Conclusion Important evidence can be provided by the combined detection of CA 153、CAl 25、CAl 99、CEA about the early diagnosis of Mammary gland malignant tumors and the differential diagnosis of benign and malignant breast tumors.
