CAJ | 학술논문

目的：观察比较XELOX（奥沙利铂、卡培他滨）与FOLFOX（奥沙利铂、氟尿嘧啶、甲酰四氢叶酸钙）化疗方案对进展期胃癌的临床疗效及不良反应。方法选取胃癌根治性切除术前接受新辅助化疗的Ⅱ～Ⅲ期81例胃癌患者为研究对象，分别纳入XELOX组（26例）与FOLFOX组（25例），将单纯手术治疗的进展期胃癌患者（30例）纳入对照组，比较3组患者根治性手术切除率及术后并发症。结果 XELOX组与FOLFOX组术前化疗疗效差异无统计学意义（P＞0．05），但FOLFOX 组不良反应发生率高于XELOX 组（P＜0．05）。XELOX组与FOLFOX组患者根治性切除率均显著高于对照组（P＜0．05），而3组术后并发症发生率差异无统计学意义（P＞0．05）。结论新辅助化疗可提高进展期胃癌根治性切除率，不增加术后并发症，XELOX安全性更高。
목적：관찰비교XELOX（오사리박、잡배타빈）여FOLFOX（오사리박、불뇨밀정、갑선사경협산개）화료방안대진전기위암적림상료효급불량반응。방법선취위암근치성절제술전접수신보조화료적Ⅱ～Ⅲ기81례위암환자위연구대상，분별납입XELOX조（26례）여FOLFOX조（25례），장단순수술치료적진전기위암환자（30례）납입대조조，비교3조환자근치성수술절제솔급술후병발증。결과 XELOX조여FOLFOX조술전화료료효차이무통계학의의（P＞0．05），단FOLFOX 조불량반응발생솔고우XELOX 조（P＜0．05）。XELOX조여FOLFOX조환자근치성절제솔균현저고우대조조（P＜0．05），이3조술후병발증발생솔차이무통계학의의（P＞0．05）。결론신보조화료가제고진전기위암근치성절제솔，불증가술후병발증，XELOX안전성경고。
Objective To observe the recent clinical effects and toxicity in advanced gastric carcinoma by neo-adjuvant chemo-therapy FOLFOX and XELOX .Methods A total of 81 patients with Ⅱ ~ Ⅲ level of gastric cancer underwent neo-adjuvant chemo-therapy before curative resection were collected ,and divided into two groups ,as XELOX group(n=26) and FOLFOX group(n=25) .30 patients who just underwent surgical treatment did not received neo-adjuvant chemotherapy were taken into control group(n=30) .The curative resection rate and complications were compared in three groups .Results There were no obvious differences be-tween XELOX group and FOLFOX group in recent clinical effect (P>0 .05) ,but FOLFOX group had higher toxic reaction rate (P<0 .05) .The curative resection rates of XELOX group and FOLFOX group were higher than that of control group (P<0 .05) . The complication rates in three groups showed no significant difference (P>0 .05) .Conclusion Neo-adjuvant chemotherapy could increase the curative resection rate of advanced gastric cancer ,which does not increase the complications ,and the program XELOX had less toxic reaction .