CAJ | 학술논문

目的：探讨早期喘息的婴幼儿血清基质金属蛋白酶-9（MMP-9）、基质金属蛋白酶抑制因子-1（TIMP-1）及血管内皮生长因子（V EG F ）水平的变化及其临床意义。方法采用酶联免疫吸附试验检测116例喘息婴幼儿（喘息组）和36例健康婴幼儿（对照组）血清MMP-9、TIMP-1和 VEGF水平。结果喘息组血清 MMP-9、TIMP-1和 VEGF水平明显高于对照组（P＜0．05）；喘息组MMP-9与 VEGF之间呈直线正相关关系（P＜0．05）；喘息组 MMP-9/TIMP-1比值低于对照组（P＜0．05）。结论早期喘息婴幼儿存在气道重塑的危险因素；检测血清MMP-9、TIMP-1和VEGF水平对判断预后，尽早进行干预治疗具有一定的指导意义。
목적：탐토조기천식적영유인혈청기질금속단백매-9（MMP-9）、기질금속단백매억제인자-1（TIMP-1）급혈관내피생장인자（V EG F ）수평적변화급기림상의의。방법채용매련면역흡부시험검측116례천식영유인（천식조）화36례건강영유인（대조조）혈청MMP-9、TIMP-1화 VEGF수평。결과천식조혈청 MMP-9、TIMP-1화 VEGF수평명현고우대조조（P＜0．05）；천식조MMP-9여 VEGF지간정직선정상관관계（P＜0．05）；천식조 MMP-9/TIMP-1비치저우대조조（P＜0．05）。결론조기천식영유인존재기도중소적위험인소；검측혈청MMP-9、TIMP-1화VEGF수평대판단예후，진조진행간예치료구유일정적지도의의。
Objective To study the changes and clinical significance of serum matrix metalloproteinase-9(MMP-9) ,tissue inhibi-tor of metalloproteinase-1(TIMP-1) and vascular endothelial growth factor (VEGF) in infants with early wheezing .Methods Ser-um levels of MMP-9 ,TIMP-1 and VEGF in 116 infants with early wheezing(wheeling group)and 36 healthy infant (control group) were detected by using ELISA .Results Serum levels of MMP-9 ,TIMP-1 and VEGF in wheeling group were significantly higher than those in control group(P<0 .05);In wheeling group ,there was a linear relationship between the level of MMP-9 and VEGF ;the ratio of MMP-9/TIMP-1 was significantly lower in wheeling groups than in control group(P<0 .05) .Conclusion The infants with early wheezing have the dangerous of airway remodeling .Detection of serum levels of MMP-9 ,TIMP-1 and VEGF is of a cer-tain significance for intervention therapy to wheezing infants as early as possible .