CAJ | 학술논문

目的：观察舌下免疫治疗对螨虫引起的儿童常年性变应性鼻炎疗效。方法选择由尘螨引起的常年性变应性鼻炎患儿61例。随机分为舌下含服组（A组）27例，常规药物组（B组）34例。观察治疗6个月、1、2年两组临床症状、体征评分变化，比较两组疗程结束后疗效及停药2年内复发情况。结果治疗6个月后A组症状评分降为（3．70±1．54）分，高于B组（2．82±1．40）分，A组体征评分降为（1．19±0．68）分，与B组差异无统计学意义；治疗1、2年时两组症状与体征评分均无进一步改变。停止治疗时，A组有效率74．07％，B组82．35％，差异无统计学意义；停止治疗后2年内复发率A组29．63％，B组94．12％，差异有统计学意义（P＜0．01）。结论舌下含服对尘螨引起的儿童常年性变应性鼻炎有较好的脱敏效果。
목적：관찰설하면역치료대만충인기적인동상년성변응성비염료효。방법선택유진만인기적상년성변응성비염환인61례。수궤분위설하함복조（A조）27례，상규약물조（B조）34례。관찰치료6개월、1、2년량조림상증상、체정평분변화，비교량조료정결속후료효급정약2년내복발정황。결과치료6개월후A조증상평분강위（3．70±1．54）분，고우B조（2．82±1．40）분，A조체정평분강위（1．19±0．68）분，여B조차이무통계학의의；치료1、2년시량조증상여체정평분균무진일보개변。정지치료시，A조유효솔74．07％，B조82．35％，차이무통계학의의；정지치료후2년내복발솔A조29．63％，B조94．12％，차이유통계학의의（P＜0．01）。결론설하함복대진만인기적인동상년성변응성비염유교호적탈민효과。
Objective To observe the efficacy of the sublingual immunotherapy in children with perennial allergic rhinitis caused by mites .Methods A total of 61 pediatric patients with perennial allergic rhinitis caused by mite in otorhinolaryngology clinic were collected .The children were randomized into two groups :27 cases were divided into sublingual dust mite drops group(group A) , and 34 cases were divided into conventional treatment group (group B) .The symptom scores and sign scores of allergic rhinitis were observed after 6 months ,1 year and 2 years of treatment .Both the efficacy at the end of treatment and the rate of recurrence following 2 years were compared between the two groups .Results After six month of treatment ,the symptom scores in group A was reduced to (3 .70 ± 1 .54)scores ,higher than group B(2 .82 ± 1 .40)scores ,while sign scores in group A was reduced to (1 .19 ± 0 .68)scores ,having no statistically significance compared with group B ,Both symptom scores and sign scores were not changed sig-nificantly after 1 and 2 years of treatment .The efficacy evaluation was 74 .07% in group A ,and 82 .35% in group B .The difference had no statistical difference .The recurrence rate in group A was 29 .63% following 2 years after terminal treatment ,and was superi-or to those in group B (94 .12% ) ,with significant difference(P<0 .01) .Conclusion Dust mite drops sublingual immunotherapy is effective measures for the treatment of children with allergic rhinitis caused by mites .