重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2013年
30期
3612-3614
,共3页
熊德明%张瑶%王国平%李刚%徐晓刚%冉文华%刘学芬
熊德明%張瑤%王國平%李剛%徐曉剛%冉文華%劉學芬
웅덕명%장요%왕국평%리강%서효강%염문화%류학분
胃肿瘤%FOXC2%Vimentin%EM T
胃腫瘤%FOXC2%Vimentin%EM T
위종류%FOXC2%Vimentin%EM T
stomach neoplasms%FOXC2%Vimentin%EM T
目的：探讨人叉头框C2（FOXC2）和Vimentin蛋白在胃癌组织中的表达和意义。方法采用免疫组化S-P法检测65例胃癌组织及20例正常胃黏膜中FOXC2和Vimentin的表达，分析两种蛋白与胃癌临床特征之间的关系及两者的相关性。结果胃癌组织中 FOXC2和 Vimentin均呈现高表达，FOXC2和 Vimentin在胃癌组织中的阳性表达率分别为41．53％和35．38％。FOXC2在中晚期胃癌的表达率为58．60％，明显高于早期胃癌表达率27．78％（P＝0．012）；FOXC2在有淋巴结转移组中的表达率为55．88％，明显高于无淋巴结转移组表达率29．03％（P＝0．018）。Vimentin在中晚期胃癌的表达率为51．72％，明显高于早期胃癌表达率22．22％（ P ＝0．013）；在有淋巴结转移组的表达率为41．20％，高于无淋巴结转移组表达率14．80％（ P＝0．010）。胃癌组织中FOXC2与Vimentin的表达呈正相关（P＝0．037）。结论 FOXC2和Vimentin可能参与了上皮细胞间质转化过程，在胃癌转移中扮演重要角色。
目的：探討人扠頭框C2（FOXC2）和Vimentin蛋白在胃癌組織中的錶達和意義。方法採用免疫組化S-P法檢測65例胃癌組織及20例正常胃黏膜中FOXC2和Vimentin的錶達，分析兩種蛋白與胃癌臨床特徵之間的關繫及兩者的相關性。結果胃癌組織中 FOXC2和 Vimentin均呈現高錶達，FOXC2和 Vimentin在胃癌組織中的暘性錶達率分彆為41．53％和35．38％。FOXC2在中晚期胃癌的錶達率為58．60％，明顯高于早期胃癌錶達率27．78％（P＝0．012）；FOXC2在有淋巴結轉移組中的錶達率為55．88％，明顯高于無淋巴結轉移組錶達率29．03％（P＝0．018）。Vimentin在中晚期胃癌的錶達率為51．72％，明顯高于早期胃癌錶達率22．22％（ P ＝0．013）；在有淋巴結轉移組的錶達率為41．20％，高于無淋巴結轉移組錶達率14．80％（ P＝0．010）。胃癌組織中FOXC2與Vimentin的錶達呈正相關（P＝0．037）。結論 FOXC2和Vimentin可能參與瞭上皮細胞間質轉化過程，在胃癌轉移中扮縯重要角色。
목적：탐토인차두광C2（FOXC2）화Vimentin단백재위암조직중적표체화의의。방법채용면역조화S-P법검측65례위암조직급20례정상위점막중FOXC2화Vimentin적표체，분석량충단백여위암림상특정지간적관계급량자적상관성。결과위암조직중 FOXC2화 Vimentin균정현고표체，FOXC2화 Vimentin재위암조직중적양성표체솔분별위41．53％화35．38％。FOXC2재중만기위암적표체솔위58．60％，명현고우조기위암표체솔27．78％（P＝0．012）；FOXC2재유림파결전이조중적표체솔위55．88％，명현고우무림파결전이조표체솔29．03％（P＝0．018）。Vimentin재중만기위암적표체솔위51．72％，명현고우조기위암표체솔22．22％（ P ＝0．013）；재유림파결전이조적표체솔위41．20％，고우무림파결전이조표체솔14．80％（ P＝0．010）。위암조직중FOXC2여Vimentin적표체정정상관（P＝0．037）。결론 FOXC2화Vimentin가능삼여료상피세포간질전화과정，재위암전이중분연중요각색。
Objective To investigate the expression and effect of FOXC2 (forkhead box C2) and Vimentin in gastric carcinoma tissues .Methods To detect the protein expression of FOXC2 and Vimentin in 20 normal gastric tissues and 65 gastric carcinoma tissues with immunochemistry .Results FOXC2 and Vimentin were highly expressed in all gastric carcinoma tissues .In all gastric carcinoma cases ,the FOXC2 expression rate was 41 .53% ,the rate of Vimentin was 35 .38% .The average expression rates of FOXC2 and Vimentin in TNM ( Ⅲ + Ⅳ ) group were significantly higher than those in TNM (Ⅰ + Ⅱ ) group ,respectively (58 .60% vs .27 .78% ,P=0 .012 ;55 .88% vs .29 .03% ,P=0 .018) .The expression rates of FOXC2 and Vimentin in lymph node transfer group were statistically higher than those in no lymph node transfer group (51 .72% vs .22 .22% ,P=0 .013;41 .20% vs . 14 .80% ,P=0 .010) .The correlation between FOXC2 and Vimentin was positive (P= 0 .037) .Conclusion It is possible that FOXC2 and Vimentin are involved in the transformation of epithelial cells into the mesenchymal cells .And they may play an impor-tant role in the metastasis of gastric carcinoma .
