重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2013年
30期
3606-3609
,共4页
甄海宁%河井信行%冈田真树%大久保修一%费舟%章翔%刘卫平%霍军丽%田宫隆
甄海寧%河井信行%岡田真樹%大久保脩一%費舟%章翔%劉衛平%霍軍麗%田宮隆
견해저%하정신행%강전진수%대구보수일%비주%장상%류위평%곽군려%전궁륭
正电子发射体层成像%11C-蛋氨酸%细胞增殖%新生血管化,病理性%神经胶质瘤
正電子髮射體層成像%11C-蛋氨痠%細胞增殖%新生血管化,病理性%神經膠質瘤
정전자발사체층성상%11C-단안산%세포증식%신생혈관화,병이성%신경효질류
positron emission tomography%11 C-methionine%cell proliferation%neovascularization,pathologic%glioma
目的：探讨人脑胶质瘤中11 C-蛋氨酸（11 C-M ET ）摄取量与细胞增殖和血管形成的关系。方法对30例新诊断的脑胶质瘤患者行11C-MET PET检查，计算11C-MET最大标准化摄取值（SUVmax）；采用免疫组化方法检测Ki-67和CD34抗原在相同脑胶质瘤标本中的表达，计算Ki-67标记指数（Ki-67 LI）和微血管密度（MVD）。结果11 C-MET SUVmax和Ki-67 LI均随胶质瘤病理级别的升高而明显增加（P＝0．000，P＝0．000）；在高恶性度胶质瘤中11C-MET SUVmax和Ki-67 LI均明显高于低恶性度胶质瘤（P＝0．000，P＝0．000）；而MVD在胶质瘤不同病理级别间（P＝0．831）以及高、低恶性度胶质瘤间（P＝0．370）均无明显差异。11C-MET SUVmax与Ki-67 LI存在明显正相关（P＝0．000），而11C-MET SUVmax与MVD（P＝0．154）以及 Ki-67 LI与MVD（P＝0．842）之间均无明显相关性。结论11C-MET摄取量和细胞增殖活性可较好地反映胶质瘤病理级别和恶性程度。
目的：探討人腦膠質瘤中11 C-蛋氨痠（11 C-M ET ）攝取量與細胞增殖和血管形成的關繫。方法對30例新診斷的腦膠質瘤患者行11C-MET PET檢查，計算11C-MET最大標準化攝取值（SUVmax）；採用免疫組化方法檢測Ki-67和CD34抗原在相同腦膠質瘤標本中的錶達，計算Ki-67標記指數（Ki-67 LI）和微血管密度（MVD）。結果11 C-MET SUVmax和Ki-67 LI均隨膠質瘤病理級彆的升高而明顯增加（P＝0．000，P＝0．000）；在高噁性度膠質瘤中11C-MET SUVmax和Ki-67 LI均明顯高于低噁性度膠質瘤（P＝0．000，P＝0．000）；而MVD在膠質瘤不同病理級彆間（P＝0．831）以及高、低噁性度膠質瘤間（P＝0．370）均無明顯差異。11C-MET SUVmax與Ki-67 LI存在明顯正相關（P＝0．000），而11C-MET SUVmax與MVD（P＝0．154）以及 Ki-67 LI與MVD（P＝0．842）之間均無明顯相關性。結論11C-MET攝取量和細胞增殖活性可較好地反映膠質瘤病理級彆和噁性程度。
목적：탐토인뇌효질류중11 C-단안산（11 C-M ET ）섭취량여세포증식화혈관형성적관계。방법대30례신진단적뇌효질류환자행11C-MET PET검사，계산11C-MET최대표준화섭취치（SUVmax）；채용면역조화방법검측Ki-67화CD34항원재상동뇌효질류표본중적표체，계산Ki-67표기지수（Ki-67 LI）화미혈관밀도（MVD）。결과11 C-MET SUVmax화Ki-67 LI균수효질류병리급별적승고이명현증가（P＝0．000，P＝0．000）；재고악성도효질류중11C-MET SUVmax화Ki-67 LI균명현고우저악성도효질류（P＝0．000，P＝0．000）；이MVD재효질류불동병리급별간（P＝0．831）이급고、저악성도효질류간（P＝0．370）균무명현차이。11C-MET SUVmax여Ki-67 LI존재명현정상관（P＝0．000），이11C-MET SUVmax여MVD（P＝0．154）이급 Ki-67 LI여MVD（P＝0．842）지간균무명현상관성。결론11C-MET섭취량화세포증식활성가교호지반영효질류병리급별화악성정도。
Objective To investigate the relation of 11C-methionine (11C-MET) uptake with cell proliferation and angiogenesis in human brain gliomas .Methods For 30 cases of newly diagnosed glioma patients ,positron emission tomography (PET ) examina-tion with 11C-MET was performed ,and the maximal standardized uptake value (SUVmax) of 11C-MET was measured .Expression of Ki-67 and CD34 antigens was examined by immunohistochemistry method in the same glioma samples ,both Ki-67 labeling index (Ki-67 LI) and microvessel density (MVD) were measured .Results Both 11C-MET SUVmax and Ki-67 LI increased significantly with glioma pathological grade ascending (P=0 .000 ,P=0 .000) ,and which in malignant glioma tissues were significantly higher than those in benign glioma tissues as well (P=0 .000 ,P=0 .000);however ,there were not significant differences in MVD among different grades of gliomas (P=0 .831) as well as between high and low malignant gliomas (P=0 .370) .11 C-MET SUVmax was significantly positively correlated with Ki-67 LI (P= 0 .000) ,however ,there were not significant correlations between 11C-MET SUVmax and MVD (P=0 .154) as well as between Ki-67 LI and MVD (P=0 .842) .Conclusion 11C-MET uptake and cell prolif-eration activity can better reflect the pathological grades and malignant degrees of gliomas .
