CAJ | 학술논문

目的：了解慢性丙型肝炎并2型糖尿病患者基因型及相应的临床特征。方法检测88例慢性丙型肝炎并2型糖尿病患者与770例慢性丙型肝炎患者基因分型，分析88例慢性丙型肝炎并2型糖尿病患者的糖化血红蛋白、空腹血糖、空腹胰岛素、天门冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）、γ-谷氨酰转肽酶（GGT）、总胆红素（TBil）、HCV RNA病毒载量及血甘油三酯等临床相关指标，并调查患者糖尿病确诊时间及抗病毒治疗情况。结果慢性丙型肝炎并2型糖尿病患者3a基因型占11.36%（10/88），高于未合并2型糖尿病者3a基因型3.38%（26/770），差异具有统计学意义（χ2=7.248，P=0.002）；并2型糖尿病的3a基因型患者的甘油三酯高于其他基因型（t=2.271，P =0.028）；糖尿病诊断时间多在抗病毒治疗前，部分患者控制血糖同时抗病毒治疗。结论感染丙型肝炎病毒3a基因型的患者更易并2型糖尿病，应监测血糖情况，尽早筛查糖尿病，早期诊治。
목적：료해만성병형간염병2형당뇨병환자기인형급상응적림상특정。방법검측88례만성병형간염병2형당뇨병환자여770례만성병형간염환자기인분형，분석88례만성병형간염병2형당뇨병환자적당화혈홍단백、공복혈당、공복이도소、천문동안산안기전이매（AST）、병안산안기전이매（ALT）、γ-곡안선전태매（GGT）、총담홍소（TBil）、HCV RNA병독재량급혈감유삼지등림상상관지표，병조사환자당뇨병학진시간급항병독치료정황。결과만성병형간염병2형당뇨병환자3a기인형점11.36%（10/88），고우미합병2형당뇨병자3a기인형3.38%（26/770），차이구유통계학의의（χ2=7.248，P=0.002）；병2형당뇨병적3a기인형환자적감유삼지고우기타기인형（t=2.271，P =0.028）；당뇨병진단시간다재항병독치료전，부분환자공제혈당동시항병독치료。결론감염병형간염병독3a기인형적환자경역병2형당뇨병，응감측혈당정황，진조사사당뇨병，조기진치。
Objective To investigate the genotype and clinical characteristics of chronic hepatitis C patients combined with type 2 diabetes mellitus (T2DM). Methods Genotype distribution analysis was taken place in 88 chronic hepatitis C patients combined with T2DM and 770 patients with barely chronic hepatitis C, comparison has been made retrospectively upon glycosylated hemoglobin, fasting glucose, fasting insulin, aspartate aminotransferase (AST), alanine aminotransferase (ALT),γ-glutamyl (GGT), total bilirubin (TBil), HCV RNA load and blood triglycerides, as well as investigated their diabetes mellitus diagnosis time and antivirus therapy status. Results The occupation ratio of HCV 3a genotype in chronic hepatitis C patients combined with T2DM was signiifcantly higher than that of patients with barely chronic hepatitis C (11.36%vs 3.38%;χ2=7.248, P=0.002). Blood triglycerides of patients infected with HCV genotype 3a combined with T2DM was signiifcantly higher than other counterparts (t=2.271, P=0.028). Diabetes mellitus diagnosis time precedes antivirus therapy in most of patients, while antivirus therapy took place simultaneously with blood glucose control in part of them. Conclusions Patients infected with HCV genotype 3a would be more likely to develop type 2 diabetes. These patients are advised to monitor blood glucose on time and screen for diabetes mellitus.