CAJ | 학술논문

目的：分析手足口病并神经系统损害的早期临床表现及脑脊液特点，为手足口病并神经系统损害的早期诊断提供依据。方法回顾性分析本院2232例手足口病中合并神经系统损害653例的年龄分布、早期临床表现、病原体及脑脊液改变特点。结果653例多发于6个月～3岁，病原体以肠道病毒71型为主，早期表现多有持续发热、易惊、肢体抖动、嗜睡、易激惹、呕吐、头痛或头晕、肢体无力、抽搐等表现，脑脊液有程度不同的氯化物降低、白细胞或蛋白增高。结论手足口病合并神经系统损害常在早期就存在不同的非特异性临床表现和脑脊液改变，应引起重视，及时予以诊断和治疗。
목적：분석수족구병병신경계통손해적조기림상표현급뇌척액특점，위수족구병병신경계통손해적조기진단제공의거。방법회고성분석본원2232례수족구병중합병신경계통손해653례적년령분포、조기림상표현、병원체급뇌척액개변특점。결과653례다발우6개월～3세，병원체이장도병독71형위주，조기표현다유지속발열、역량、지체두동、기수、역격야、구토、두통혹두훈、지체무력、추휵등표현，뇌척액유정도불동적록화물강저、백세포혹단백증고。결론수족구병합병신경계통손해상재조기취존재불동적비특이성림상표현화뇌척액개변，응인기중시，급시여이진단화치료。
Objective To analyze the early clinical manifestations and cerebrospinal fluid characteristics of hand, foot and mouth diseases (HFMD) and nerve system damage, provides foundation for early diagnosis of HFMD and nerve system damage. Methods Total of 653 cases of the nervous system damage in 2232 cases with HFMD in our hospital. The distribution of age, early clinical manifestations pathogen and cerebrospinal lfuid change characteristics of 653 cases were analyzed, retrospectively. Results Most of 653 cases were in 6 months to 3 years old,enterovirus type 71 (EV71) was the major pathogens, the early performance were persistent fever, skittishness, limb jitter, sleepiness, autism, vomiting, headache and dizziness, body weakness, convulsions and so on. Cerebrospinal lfuid had different degrees of chloride reducing, and the white blood cells or protein increased. Conclusions Hand, foot and mouth disease complicated with nervous system damage have different nonspeciifc clinical manifestations and cerebrospinal lfuid change in the early stage, which should be takn seriously, and diagnosed and treated timely.