中华实验和临床感染病杂志（电子版）
中華實驗和臨床感染病雜誌（電子版）
중화실험화림상감염병잡지（전자판）
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL INFECTIOUS DISEASES(ELECTRONIC VERSION)
2013年
4期
519-522
,共4页
张婷%王艳斌%王京京%赵红%皇甫竞坤%范颖%程澄%闫杰%谢雯%成军
張婷%王豔斌%王京京%趙紅%皇甫競坤%範穎%程澄%閆傑%謝雯%成軍
장정%왕염빈%왕경경%조홍%황보경곤%범영%정징%염걸%사문%성군
骨软化症%阿德福韦酯%肝炎,乙型
骨軟化癥%阿德福韋酯%肝炎,乙型
골연화증%아덕복위지%간염,을형
Osteomalacia%Adefovir%Hepatitis B
目的：进一步探讨阿德福韦酯（ADV）所致低磷性骨软化症的临床特点。方法回顾性分析2010至2012年共收治的8例慢性乙型肝炎患者经ADV治疗所致低磷性骨软化症的临床表现、治疗和转归。结果8例患者均在服用ADV后出现低磷血症及骨质疏松，其主要临床表现为乏力、多发骨痛，进行加重至行走障碍；低血磷、低尿酸和高碱性磷酸酶血症、骨密度检查提示骨质疏松。经停用ADV、对症补钙、补磷治疗后患者的血磷恢复正常，疼痛缓解，骨质疏松改善。结论 ADV可引起低磷性骨软化症；补充磷、维生素D3及钙剂治疗可恢复。
目的：進一步探討阿德福韋酯（ADV）所緻低燐性骨軟化癥的臨床特點。方法迴顧性分析2010至2012年共收治的8例慢性乙型肝炎患者經ADV治療所緻低燐性骨軟化癥的臨床錶現、治療和轉歸。結果8例患者均在服用ADV後齣現低燐血癥及骨質疏鬆，其主要臨床錶現為乏力、多髮骨痛，進行加重至行走障礙；低血燐、低尿痠和高堿性燐痠酶血癥、骨密度檢查提示骨質疏鬆。經停用ADV、對癥補鈣、補燐治療後患者的血燐恢複正常，疼痛緩解，骨質疏鬆改善。結論 ADV可引起低燐性骨軟化癥；補充燐、維生素D3及鈣劑治療可恢複。
목적：진일보탐토아덕복위지（ADV）소치저린성골연화증적림상특점。방법회고성분석2010지2012년공수치적8례만성을형간염환자경ADV치료소치저린성골연화증적림상표현、치료화전귀。결과8례환자균재복용ADV후출현저린혈증급골질소송，기주요림상표현위핍력、다발골통，진행가중지행주장애；저혈린、저뇨산화고감성린산매혈증、골밀도검사제시골질소송。경정용ADV、대증보개、보린치료후환자적혈린회복정상，동통완해，골질소송개선。결론 ADV가인기저린성골연화증；보충린、유생소D3급개제치료가회복。
Objective To investigate the clinical features of hypophosphatemic osteomalacia induced by adefovir dipivoxil treatment for patients with chronic hepatits B. Methods Total of 8 patients with hypophosphatemic osteomalaciachonic induced by adefovir dipivoxil treatment for chronic hepatits B from 2010 to 2012 admitted in our hospital were clinically analyzed. Results All patients occured hypophosphatemic osteomalacia after application of adefovir dipivoxil, with the main clinical manifestations as fatigue, multiple bone pain and progressive walking problems. Reduced serum phosphate level, low uric acid and high alkaline phosphatase hyperlipidemia, bone density examinations all showed osteoporosis. Hypophosphatemia was improved after discontinuation of adefovir dipivoxil and supplement with phosphorus and calcium. Conclusions Adefovir dipivoxil treatment could induce hypophosphatemic osteomalacia. Patients supplemented with vitamin D3 and calcium got cured.
