中华实验和临床感染病杂志（电子版）
中華實驗和臨床感染病雜誌（電子版）
중화실험화림상감염병잡지（전자판）
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL INFECTIOUS DISEASES(ELECTRONIC VERSION)
2013年
4期
484-486
,共3页
临床中由不同的细菌，真菌和病毒感染所致的感染性疾病的患者免疫缺陷包括原发性或获得性免疫缺陷两大类，前者因遗传基因缺陷引起，后者因HIV感染所致。新的获得性免疫缺陷逐渐浮出水面，其发病机制特殊，本文介绍该方面的临床感染和免疫学研究的进展，着重强调强中和力抗-IFN-γ所致的分枝杆菌易感综合征，另名为成人起病型免疫缺陷；同时介绍其他中和性抗细胞因子抗体所致的获得性免疫缺陷及其相关感染。这一领域的快速发展，会发现更多与传染性疾病有关的致病性抗体。
臨床中由不同的細菌，真菌和病毒感染所緻的感染性疾病的患者免疫缺陷包括原髮性或穫得性免疫缺陷兩大類，前者因遺傳基因缺陷引起，後者因HIV感染所緻。新的穫得性免疫缺陷逐漸浮齣水麵，其髮病機製特殊，本文介紹該方麵的臨床感染和免疫學研究的進展，著重彊調彊中和力抗-IFN-γ所緻的分枝桿菌易感綜閤徵，另名為成人起病型免疫缺陷；同時介紹其他中和性抗細胞因子抗體所緻的穫得性免疫缺陷及其相關感染。這一領域的快速髮展，會髮現更多與傳染性疾病有關的緻病性抗體。
림상중유불동적세균，진균화병독감염소치적감염성질병적환자면역결함포괄원발성혹획득성면역결함량대류，전자인유전기인결함인기，후자인HIV감염소치。신적획득성면역결함축점부출수면，기발병궤제특수，본문개소해방면적림상감염화면역학연구적진전，착중강조강중화력항-IFN-γ소치적분지간균역감종합정，령명위성인기병형면역결함；동시개소기타중화성항세포인자항체소치적획득성면역결함급기상관감염。저일영역적쾌속발전，회발현경다여전염성질병유관적치병성항체。
Patients with either primary or acquired immune deficiency presented with clinical susceptibilities to infectious diseases caused by different bacteria, fungi and viruses. The major difference between primary and acquired deficiency was based on the etiologies, due to either genetic defects or HIV infection. A new subset of acquired immune deficiency was defined recently due to the occurrence of neutralizing antibodies against cytokines. Patients with neutralizing antibodies against IFN-γ showed severe opportunistic intracellular bacterial infection, which was similar to the clinical phenotypes of patients with mendelian susceptibility to Mycobacterial disease (MSMD). More neutralizing antibodies against other cytokines were also reported to confer susceptibilities to different pathogens, including staphylococcus, Candida albican, Cryptococcus neoformans and so on. This ifeld is evolving quickly with more pathogenic antibodies to be associated with infectious diseases.
