CAJ | 학술논문

目的：观察复方牙痛贴膜的抗炎镇痛作用。方法：以解痉镇痛酊为对照药物,采用热板致痛法、醋酸扭体法、二甲苯致炎法,观察复方牙痛贴膜的抗炎镇痛作用。结果：复方牙痛贴膜高、中、低剂量组与解痉镇痛酊组相比,给药后30 min到90 min痛阈值差异无统计学意义（P>0.05）,120 min后,差异具有统计学意义（P<0.05）。随着剂量增加,膜剂各剂量组小鼠扭体次数减少,与对照组相比,差异均具有统计学意义（P<0.05）,膜剂中、高剂量组和解痉镇痛酊组的扭体抑制率,分别为44.33%、68.22%、71.86%。膜剂高、中、低剂量组与解痉镇痛酊组耳廓肿胀抑制率分别为56.52%、36.96%、13.04%、45.65%,肿胀度与对照组比较,差异均具有统计学意义（P<0.05）。膜剂各剂量组小鼠耳廓染料渗出液吸光度值与解痉镇痛酊组比较,差异无统计学意义（P>0.05）。结论：复方牙痛贴膜具有较强的抗炎镇痛作用,是一种疗效较好的外用制剂。
목적：관찰복방아통첩막적항염진통작용。방법：이해경진통정위대조약물,채용열판치통법、작산뉴체법、이갑분치염법,관찰복방아통첩막적항염진통작용。결과：복방아통첩막고、중、저제량조여해경진통정조상비,급약후30 min도90 min통역치차이무통계학의의（P>0.05）,120 min후,차이구유통계학의의（P<0.05）。수착제량증가,막제각제량조소서뉴체차수감소,여대조조상비,차이균구유통계학의의（P<0.05）,막제중、고제량조화해경진통정조적뉴체억제솔,분별위44.33%、68.22%、71.86%。막제고、중、저제량조여해경진통정조이곽종창억제솔분별위56.52%、36.96%、13.04%、45.65%,종창도여대조조비교,차이균구유통계학의의（P<0.05）。막제각제량조소서이곽염료삼출액흡광도치여해경진통정조비교,차이무통계학의의（P>0.05）。결론：복방아통첩막구유교강적항염진통작용,시일충료효교호적외용제제。
ObjectiveTo observe the anti-inflammatory and analgesic effects of Fufangyatong film. MethodsWith the original drug Jiejingzhentong tincture as a contrast,the hot-plate, acetic acid body twist and xylene-induced inflammation test were used to observe the anti-inflammatory and analgesic effect of Fufangyatong film. Results In hot-plate test,the pain threshold of film groups and tincture group after 30min to 90 min had no significant difference,but there was significant difference after 120 min. The body twist was reduced with the increas of dosage in film groups;there was significant diffenence compared with the control group. The repression rates of the ear swelling in high,medium and low dosage film group and the tincture group were 56.52%,36.96%,13.04% and 45.65% respectively,there were significant differences. There was no statistic significance about the difference of the dye effusion among all the drug groups. Conclusion: Fufangyatong film has stronger and longer anti-inflammatory and analgesic function,and it is a preparation for external use with better efficacy.