CAJ | 학술논문

目的：通过探讨缺血性中风中医辨证分型与血浆TXB2及6-keto-PGF1α之间的关系,力图进一步揭示缺血性中风各证型的本质及演变规律,筛选出能反映中医证候客观化的敏感指标。方法：以泸州地区200名急性缺血性中风患者作为研究对象,辨证分型,分组进行对比研究。结果：缺血性中风患者TXB2和6-keto-PGF1α存在明显直线相关和回归关系。缺血性中风不同中医证型组TXB2与6-keto-PGF1α值均成明显直线相关和回归关系：风痰瘀血闭阻脉络组直线回归方程为Y （TXB2）=691.79+0.56X（6-keto-PGF1α）,（R=0.417,P=0.003<0.01,回归方程成立）；风痰上扰痰热腑实组直线回归方程为Y（TXB2）=401.51+0.58X（6-keto-PGF1α）,（R=0.491,P=0.000<0.01,回归方程成立）；气虚血瘀组直线回归方程为Y（TXB2）=150.10+1.11X（6-keto-PGF1α）,（R=0.638,P=0.001<0.01,回归方程成立）；阴虚风动组直线回归方程为Y（TXB2）=184.19+0.91X（6-keto-PGF1α）,（R=0.638,P=0.000<0.01,回归方程成立）。结论：TXB2及6-keto-PGF1α可以作为缺血性中风中医证型的客观化指标之一。
목적：통과탐토결혈성중풍중의변증분형여혈장TXB2급6-keto-PGF1α지간적관계,력도진일보게시결혈성중풍각증형적본질급연변규률,사선출능반영중의증후객관화적민감지표。방법：이로주지구200명급성결혈성중풍환자작위연구대상,변증분형,분조진행대비연구。결과：결혈성중풍환자TXB2화6-keto-PGF1α존재명현직선상관화회귀관계。결혈성중풍불동중의증형조TXB2여6-keto-PGF1α치균성명현직선상관화회귀관계：풍담어혈폐조맥락조직선회귀방정위Y （TXB2）=691.79+0.56X（6-keto-PGF1α）,（R=0.417,P=0.003<0.01,회귀방정성립）；풍담상우담열부실조직선회귀방정위Y（TXB2）=401.51+0.58X（6-keto-PGF1α）,（R=0.491,P=0.000<0.01,회귀방정성립）；기허혈어조직선회귀방정위Y（TXB2）=150.10+1.11X（6-keto-PGF1α）,（R=0.638,P=0.001<0.01,회귀방정성립）；음허풍동조직선회귀방정위Y（TXB2）=184.19+0.91X（6-keto-PGF1α）,（R=0.638,P=0.000<0.01,회귀방정성립）。결론：TXB2급6-keto-PGF1α가이작위결혈성중풍중의증형적객관화지표지일。
Objective: To investigate the relationship between of TCM syndromes of ischemic stroke and en-dothelial cell secretory function, in a bid to reveal the nature and effective sensitive indicator of the TCM syn-drome types. Methods: 200 patients with acute ischemic stroke in Luzhou city were differentiated according to their symptoms and signes into 4 TCM syndrome types:wind-phlegm with blood stasis and vessel block syndrome(type A),upward disturbance of wind-phlegm and excess phlegm and heat of fu-viscera syndrom(type B),Qidefi-cient and blood stasis syndrome(type C)and Yin deficient and wind-activation syndrome(type D),and compar-atively studied. Results There were significant linear and regressive correlations between TXB2 and 6-keto-PGF1α in 4 types of ischemic stroke syndrome.The regression equation in type A, B, C, D were Y (TXB2) =691.79+0.56 X (6-keto-PGF1 α), (R = 0.417, P= 0.003 <0.01), Y (TXB2) = 401.51 +0.58 X (6-keto-PGF1α), (R = 0.491, P= 0.000 <0.01), Y (TXB2) = 150.10 +1.11 X (6-keto-PGF1 α), (R = 0.638, P = 0.001<0.01), and Y (TXB2) = 184.19 +0.91 X (6-keto-PGF1 α), (R = 0.638, P= 0.000 <0.01,) respectively. Con-clusion: TXB2 and 6-keto-PGF1α can be used as the objective indicators for the differential TCM syndrome types of ischemic stroke.