CAJ | 학술논문

目的比较康复新液口服与雾化吸入法在头颈部肿瘤放疗中防治急性放射性口腔粘膜反应的临床效果.方法将200例接受放射治疗的头颈部肿瘤患者随机分为A组(口服组100例)和B组(雾化组100例).A组采用口服法,3次/d,缓慢吞服；B组采用雾化吸入法,2次/d.两组患者均于放疗开始时使用至放疗结束.结果 A组2～3级放射性粘膜炎发生率为19％,B组2～3级放射性粘膜炎发生率为33％,差异有统计学意义(x2=5.09,P＜0.05).结论康复新液口服及雾化吸入法均能减轻及缩短口腔粘膜急性放疗反应的程度及时间,单用口服法优于雾化吸入法,口服法加雾化吸入法相结合效果更好,值得临床推荐使用.
목적 비교강복신액구복여무화흡입법재두경부종류방료중방치급성방사성구강점막반응적림상효과.방법 장200례접수방사치료적두경부종류환자수궤분위A조(구복조100례)화B조(무화조100례).A조채용구복법,3차/d,완만탄복；B조채용무화흡입법,2차/d.량조환자균우방료개시시사용지방료결속.결과 A조2～3급방사성점막염발생솔위19％,B조2～3급방사성점막염발생솔위33％,차이유통계학의의(x2=5.09,P＜0.05).결론 강복신액구복급무화흡입법균능감경급축단구강점막급성방료반응적정도급시간,단용구복법우우무화흡입법,구복법가무화흡입법상결합효과경호,치득림상추천사용.
Objective To compare the efficacy of oral Kangfuxin liquid with that of aerosolized inhalation of the liquid in the prevention of acute radiation stomatitis in patients with head and neck tumors undergoing radiation therapy.Methods 200 patients with head and neck cancer were randomly divided into group A (oral group,100 patients) and group B (inhalation group,100 patients).Group A received oral Kangfuxin liquid 3 times daily,while group B received aerosolized inhalation of the liquid twice daily.The treatment lasted during the whole radiotherapy.Results The incidence rate of grades 2 to 3 radiation stomatitis was lower in group A than in group B (19％ in group A and 33％ in group B,x2=5.09,P＜0.05); there was a significant difference between the two groups.Conclusions Both oral Kangfuxin liquid and aerosolized inhalation of the liquid can reduce the severity of acute oral mucosal radiation reaction and shorten the duration of therapy.Oral Kangfuxin is better than inhalation.Combination therapy is more effective and is worth popularizing clinically.