CAJ | 학술논문

目的：考察丹参生品及5种炮制品的α-葡萄糖苷酶的抑制活性变化。方法：通过采用体外α-葡萄糖苷酶抑制模型，以阿卡波糖为阳性对照，测定α-葡萄糖苷酶抑制活性。结果：丹参生品和炮制品各部位均存在一定的α-葡萄糖苷酶抑制活性，且均高于阳性对照药阿卡波糖。除丹参炭甲醇（ME）提取物外，其他炮制丹参ME提取物对α-葡萄糖苷酶的抑制活性均大于丹参生品ME提取物；丹参炮制品石油醚（PE）部位抑制活性与丹参生品PE部位接近；丹参炮制品乙酸乙酯（EA）部位抑制活性均低于丹参生品EA部位；丹参炮制品参正丁醇（BU）部位对α-葡萄糖苷酶的抑制活性均高于丹参生品BU部位，各部位的抑制活性均与质量浓度呈正相关性，具有浓度依赖性。结论：丹参炮制品可不同程度的增加α-葡萄糖苷酶抑制活性。
목적：고찰단삼생품급5충포제품적α-포도당감매적억제활성변화。방법：통과채용체외α-포도당감매억제모형，이아잡파당위양성대조，측정α-포도당감매억제활성。결과：단삼생품화포제품각부위균존재일정적α-포도당감매억제활성，차균고우양성대조약아잡파당。제단삼탄갑순（ME）제취물외，기타포제단삼ME제취물대α-포도당감매적억제활성균대우단삼생품ME제취물；단삼포제품석유미（PE）부위억제활성여단삼생품PE부위접근；단삼포제품을산을지（EA）부위억제활성균저우단삼생품EA부위；단삼포제품삼정정순（BU）부위대α-포도당감매적억제활성균고우단삼생품BU부위，각부위적억제활성균여질량농도정정상관성，구유농도의뢰성。결론：단삼포제품가불동정도적증가α-포도당감매억제활성。
This article was aimed to evaluate the α-glucosidase inhibitory activity of extracts from the root of Salvia miltiorrhiza Bunge and different processed products. The α-glucosidase inhibitory activity was screened with acarbose as positive control and by α-glucosidase inhibitory model in v itro . The results showed that the ex-tracts from the root of S. miltiorrhiza and different processed products had inhibitory activity. And the activity was higher than that of acarbose. In addition to the MeOH extract of S. miltiorrhiza carbon, the inhibitory activity of MeOH extracts from other processed products were higher than that of MeOH extract of S. miltiorrhiza. The in-hibitory activity of petroleum ether extracts of different processed products were close to S. miltiorrhiza. EtOAC extracts were lower than that of S. miltiorrhiza. The n-BuOH extracts were higher than that of S. miltiorrhiza. The inhibitory activity of extracts was positively correlated with concentrations, and it depended on the concentra-tion. It was concluded that the processed products of S. miltiorrhiza can strengthen α-glucosidase inhibitory activ-ity in different degrees.