CAJ | 학술논문

骨是乳腺癌常见的转移部位，乳腺癌骨转移可导致骨质疏松、高血钙症、脊髓压迫和病理性骨折等并发症，严重影响患者的生活和生存质量。中医中药在治疗乳腺癌骨转移方面显示出潜在的优势。近10年研究发现，许多中药单体、提取物以及中药复方能够从不同分子机制发挥抑制乳腺癌细胞增殖、侵袭，缓解乳腺癌细胞引起的骨质破坏及癌性骨痛作用。
골시유선암상견적전이부위，유선암골전이가도치골질소송、고혈개증、척수압박화병이성골절등병발증，엄중영향환자적생활화생존질량。중의중약재치료유선암골전이방면현시출잠재적우세。근10년연구발현，허다중약단체、제취물이급중약복방능구종불동분자궤제발휘억제유선암세포증식、침습，완해유선암세포인기적골질파배급암성골통작용。
Bone is the most common metastatic site of breast cancer . And breast cancer metastasis to bone can lead to osteoporosis , hypercalcemia , spinal cord compression and pathological fracture , which seriously impact the patientsˊ quality of life and survival . Chinese herbs have a potential advantage in the treatment of breast cancer metastasis to bone. In recent ten years, a number of studies showed that Chinese medicine monomers, traditional Chinese medicine (TCM) extracts, and Chinese herbal compound prescriptions played a role in in-hibiting breast cancer cell proliferation , invading and relieving the bone destruction and bone pain by different molecular mechanisms .