CAJ | 학술논문

目的：探讨特定穴位针刺治疗对高脂饮食肥胖模型小鼠血清血管生成因子的影响。方法：小鼠随机分为空白对照组、针刺对照组、模型对照组和针刺治疗组，每组6只。小鼠15周高脂饮食制备肥胖模型后，采用特定穴位针刺法干预治疗10天，酶联免疫法检测小鼠血清胰岛素、血管内皮细胞生长因子、可溶性血管内皮细胞生长因子受体、瘦素、一氧化氮水平。结果：肥胖模型小鼠血清胰岛素、一氧化氮以及瘦素水平上升，而血清血管内皮细胞生长因子以及可溶性血管内皮细胞生长因子受体水平没有明显变化；特定穴位针刺治疗可以显著降低血清一氧化氮、瘦素水平，并可提高肥胖模型小鼠血清血管内皮细胞生长因子含量，但对血糖水平、可溶性血管内皮细胞生长因子受体水平没有影响。结论：特定穴位针刺疗法具有较好的减肥作用，其作用机制可能与调节血管再生有关。
목적：탐토특정혈위침자치료대고지음식비반모형소서혈청혈관생성인자적영향。방법：소서수궤분위공백대조조、침자대조조、모형대조조화침자치료조，매조6지。소서15주고지음식제비비반모형후，채용특정혈위침자법간예치료10천，매련면역법검측소서혈청이도소、혈관내피세포생장인자、가용성혈관내피세포생장인자수체、수소、일양화담수평。결과：비반모형소서혈청이도소、일양화담이급수소수평상승，이혈청혈관내피세포생장인자이급가용성혈관내피세포생장인자수체수평몰유명현변화；특정혈위침자치료가이현저강저혈청일양화담、수소수평，병가제고비반모형소서혈청혈관내피세포생장인자함량，단대혈당수평、가용성혈관내피세포생장인자수체수평몰유영향。결론：특정혈위침자요법구유교호적감비작용，기작용궤제가능여조절혈관재생유관。
This study was aimed to discuss the influence of specific acupoint acupuncture therapy to the serum angiogenesis factor of high fat diet obese mouse models. Mice were randomly divided into the blank control group , acupuncture control group , model control group , and acupuncture treatment group . There were 6 mice in each group . Obese mouse models were induced after 15-week high fat diet . The specific acupoint acupunc-ture therapy was used as an intervention treatment method for 10 days . The enzyme-linked immunosorbent as-say (ELISA) was used in the detection of serum insulin, vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor , leptin and the level of nitric oxide in mice . The results showed that the serum insulin , nitric oxide and leptin level in the obese mouse models were increased . However , there were no obvious changes on the vascular endothelial growth factor and soluble vascular endothelial growth fac-tor receptor level . The specific acupoint acupuncture therapy can obviously reduce the level of serum nitric ox-ide and leptin, and improve the content of vascular endothelial growth factor in obese mouse models. However, there were no influence on the level of blood glucose and soluble vascular endothelial growth factor receptor . It was concluded that the specific acupoint acupuncture therapy method had preferable antiobesity action . Its mechanism of action may be related to the regulation of angiogenesis .