CAJ | 학술논문

中药方剂（traditional Chinese medicine formula，TCMF）是中医治疗的一种主要手段。然而一首方剂往往包含多种草药，这其中只有几种草药对治疗特定的病症起重要作用。因此，找出方剂中的核心药物和其配伍规律对研究中药方剂有非常重要的意义。针对该问题，提出了一种基于效用度（effect degree，ED）的核心药物及配伍规律发现方法。该方法包含三个主要步骤，分别是基于药物效用度的核心药物发现算法、基于带药对效用度的点式互信息（pointwise mutual information with herb pair ED，PMIED）的药物组网算法、基于重叠社团的高效药物配伍规律发现算法。通过实验，发现了肺痿方剂的42种核心药物和30种药物配伍，经分析和中医专家确认，42种核心药物对肺痿确有良好疗效，30组药物配伍中有26组符合药物配伍关系且对肺痿有良好疗效。
중약방제（traditional Chinese medicine formula，TCMF）시중의치료적일충주요수단。연이일수방제왕왕포함다충초약，저기중지유궤충초약대치료특정적병증기중요작용。인차，조출방제중적핵심약물화기배오규률대연구중약방제유비상중요적의의。침대해문제，제출료일충기우효용도（effect degree，ED）적핵심약물급배오규률발현방법。해방법포함삼개주요보취，분별시기우약물효용도적핵심약물발현산법、기우대약대효용도적점식호신식（pointwise mutual information with herb pair ED，PMIED）적약물조망산법、기우중첩사단적고효약물배오규률발현산법。통과실험，발현료폐위방제적42충핵심약물화30충약물배오，경분석화중의전가학인，42충핵심약물대폐위학유량호료효，30조약물배오중유26조부합약물배오관계차대폐위유량호료효。
Traditional Chinese medicine formula (TCMF) is a main treatment measure in traditional Chinese medicine (TCM). However, a formula always contains many herbs and only some herbs play an important role in the formula, so it’s meaningful to find the core herbs and their combination rules. To solve the problem, this paper proposes an algorithm based on effect degree (ED) which includes three main steps. The three steps are core herbs discovery algorithm based on ED, network construct algorithm based on pointwise mutual information with herb pair ED (PMIED) and herb combination rules detection algorithm based on overlapping communities. Through experiments, this paper finds 42 core herbs and 30 kinds of herb groups in consumptive lung disease formulas. By analysis, all the 42 core herbs have a good effect on treatment of consumptive lung disease. Meanwhile 26 groups meet the herb combination rules and have a good effect on treatment of consumptive lung disease.