CAJ | 학술논문

目的：应用Meta分析的方法评价p16甲基化与中国人群非小细胞肺癌（NSCLC）的关系。方法：检索1978～2013年在Medline、Pubmed数据库以及1994～2013年CNKI、中国生物医学文献数据库、万方和维普数据库收录的所有有关p16甲基化与肺癌研究的文献，并用Review Manager 5.2软件进行统计分析。结果：纳入国内外标准的文献10篇，共有549例NSCLC患者，对照513例。数据合并结果显示，p16甲基化病例组与对照组的比值比（OR）为6.76，95%CI为（4.79%～9.54%）；经统计学分析有统计学意义（P＜0.05）。结论：p16甲基化与NSCLC发生有密切关系。
목적：응용Meta분석적방법평개p16갑기화여중국인군비소세포폐암（NSCLC）적관계。방법：검색1978～2013년재Medline、Pubmed수거고이급1994～2013년CNKI、중국생물의학문헌수거고、만방화유보수거고수록적소유유관p16갑기화여폐암연구적문헌，병용Review Manager 5.2연건진행통계분석。결과：납입국내외표준적문헌10편，공유549례NSCLC환자，대조513례。수거합병결과현시，p16갑기화병례조여대조조적비치비（OR）위6.76，95%CI위（4.79%～9.54%）；경통계학분석유통계학의의（P＜0.05）。결론：p16갑기화여NSCLC발생유밀절관계。
Objective:To evaluate the relationship of p16 methylation with non-small cell lung cancer (NSCLC)in Chinese populations by meta-analysis. Articles related to the p16 methylation in NSCLC published from 1978 to 2013 in the databanks including MEDLINE and published from 1978 to 2013 in the databanks including CNKI, Chinese biological medicine disk,WanFang and VIP databanks were collected, and data was analyzed by RevMan5.2 software. Results: Ten studies met our inclusion criteria, 549 NSCLC cases and 513 controls about p16 methylation were brought into the study. Odds ratios(ORs)of p16 methylation were obtained from case group and control group was 6.76(95%CI:4.79%~9.54%),Statistical analysis showed significant difference between the two groups(P<0.05).Conclusion:Methylation of p16 caused gene inactivation, and may contribute to the development of NSCLC.