CAJ | 학술논문

目的：研究萘哌地尔的合成工艺。方法以1-萘酚和环氧氯丙烷为原料，在相转移催化剂TEBA作用下反应，再与间甲氧基苯基哌嗪作用，生成萘哌地尔。结果萘哌地尔的最佳合成条件为：化合物Ⅰ与化合物Ⅱ的摩尔比为1∶1，反应温度为60℃。结论该方法有合成路线简单、反应条件温和、产物易精制等优点，完全适合工业化生产。
목적：연구내고지이적합성공예。방법이1-내분화배양록병완위원료，재상전이최화제TEBA작용하반응，재여간갑양기분기고진작용，생성내고지이。결과내고지이적최가합성조건위：화합물Ⅰ여화합물Ⅱ적마이비위1∶1，반응온도위60℃。결론해방법유합성로선간단、반응조건온화、산물역정제등우점，완전괄합공업화생산。
Objective To study the synthesis process of naftopidil.Methods Naftopidil was successfully synthesized using 1-naphthol and epichlorohydrin as materials.The two materials firstly reacted in the presence of phase transfer catalyst TEBA,then directly reac-ted with 1-(3-methoxyphenyl)piperazine.Results The optimal synthesis conditions of naftopidil:molar ratio of productⅠandⅡis 1∶1 ,reaction temperature is 60℃.Conclusions The synthetic route of the process is simple,the reaction conditions were mild,the product is easily purified,and the process is very suitable for industrialization.