现代医药卫生
現代醫藥衛生
현대의약위생
MODERN MEDICINE HEALTH
2014年
9期
1300-1301,1304
,共3页
夏凌志%彭杰雄%连丽琴%徐萌
夏凌誌%彭傑雄%連麗琴%徐萌
하릉지%팽걸웅%련려금%서맹
癌前状态%宫颈上皮内瘤样病变%乳头状瘤病毒科%基因型%液基薄层细胞检测
癌前狀態%宮頸上皮內瘤樣病變%乳頭狀瘤病毒科%基因型%液基薄層細胞檢測
암전상태%궁경상피내류양병변%유두상류병독과%기인형%액기박층세포검측
Precancerous conditions%Cervical intraepithelial neoplasia%Papillomaviridae%Genotype%Thinprep cytologic test
目的：评价人乳头瘤病毒（HPV）检测在筛查女性早期宫颈癌前病变中的临床应用价值。方法采集收治的282例宫颈筛查患者的宫颈脱落细胞，同时进行液基薄层细胞检测（TCT）及HPV基因分型检测。TCT诊断包括无上皮内病变细胞（NILM）、意义不明确的非典型鳞状上皮细胞（ASCUS）、低度鳞状上皮内病变（LSIL）、高度鳞状上皮内病变（HSIL）和鳞状细胞癌（SCC）。对结果异常者进行病理组织活检，以病理组织活检结果为诊断“金标准”。结果 HPV DNA阳性组（126例）TCT诊断NILM 53例，ASCUS 22例，LSIL 32例，HSIL 18例，SCC 1例；病理组织活检阳性率为42.86%（54/126）。HPV DNA阴性组（156例）TCT诊断NILM 133例，ASCUS 16例，LSIL 7例；病理组织活检阳性率为11.54%（18/156）。两组患者病理组织活检阳性率比较，差异有统计学意义（χ2=35.96，P<0.01）。高危型HPV检出率随宫颈病变程度增高而升高。结论对女性早期宫颈癌及其癌前病变的筛查进行HPV检测有重要现实意义。
目的：評價人乳頭瘤病毒（HPV）檢測在篩查女性早期宮頸癌前病變中的臨床應用價值。方法採集收治的282例宮頸篩查患者的宮頸脫落細胞，同時進行液基薄層細胞檢測（TCT）及HPV基因分型檢測。TCT診斷包括無上皮內病變細胞（NILM）、意義不明確的非典型鱗狀上皮細胞（ASCUS）、低度鱗狀上皮內病變（LSIL）、高度鱗狀上皮內病變（HSIL）和鱗狀細胞癌（SCC）。對結果異常者進行病理組織活檢，以病理組織活檢結果為診斷“金標準”。結果 HPV DNA暘性組（126例）TCT診斷NILM 53例，ASCUS 22例，LSIL 32例，HSIL 18例，SCC 1例；病理組織活檢暘性率為42.86%（54/126）。HPV DNA陰性組（156例）TCT診斷NILM 133例，ASCUS 16例，LSIL 7例；病理組織活檢暘性率為11.54%（18/156）。兩組患者病理組織活檢暘性率比較，差異有統計學意義（χ2=35.96，P<0.01）。高危型HPV檢齣率隨宮頸病變程度增高而升高。結論對女性早期宮頸癌及其癌前病變的篩查進行HPV檢測有重要現實意義。
목적：평개인유두류병독（HPV）검측재사사녀성조기궁경암전병변중적림상응용개치。방법채집수치적282례궁경사사환자적궁경탈락세포，동시진행액기박층세포검측（TCT）급HPV기인분형검측。TCT진단포괄무상피내병변세포（NILM）、의의불명학적비전형린상상피세포（ASCUS）、저도린상상피내병변（LSIL）、고도린상상피내병변（HSIL）화린상세포암（SCC）。대결과이상자진행병리조직활검，이병리조직활검결과위진단“금표준”。결과 HPV DNA양성조（126례）TCT진단NILM 53례，ASCUS 22례，LSIL 32례，HSIL 18례，SCC 1례；병리조직활검양성솔위42.86%（54/126）。HPV DNA음성조（156례）TCT진단NILM 133례，ASCUS 16례，LSIL 7례；병리조직활검양성솔위11.54%（18/156）。량조환자병리조직활검양성솔비교，차이유통계학의의（χ2=35.96，P<0.01）。고위형HPV검출솔수궁경병변정도증고이승고。결론대녀성조기궁경암급기암전병변적사사진행HPV검측유중요현실의의。
Objective To evaluate the clinical application values of human papilloma virus (HPV) testing in screening of women precancerous lesions of uterine cervix. Methods Cervical exfoliated cells from 282 hospitalized patients with cervical screening were collected,and the thinprep cytologic test(TCT) and HPV gene type test were conducted simultaneously. The TCT diagnosis included negative for intraepithelial lesion or malignancy (NILM),atypical squamous cells of undetermined significance (ASCUS),low-grade squamous intraepithelial lesion(LSIL),high-grade squamous intraepithelial lesion(HSIL) and squamous-cell carcinoma(SCC). The histopathologic examination was conducted to the patients with anomalous results,and the result of histopatho logic examination was regarded as golden standard of diagnosis. Results In HPV DNA positive group(n=126),the TCT showed 53 cases were of NILM,22 of ASCUS,32 of LSIL,18 of HSIL and 7 of SCC with the positive rate of histopathologic examination of 42.86%(54/126);while in HPVDNA negative group(n=156),the TCT showed 133 cases were of NILM,16 of ASCUS and 7 of LSIL with the positive rate of histopathologic examination of 11.54%(18/156). The comparison on positive rate of histopathologic examination between the two groups had statistically significant difference (χ2=35.96,P<0.01). High risk type HPV detection rate increased with the increased degree of cervical lesions. Conclusion HPV detection to female early cervical cancer and precan-cerous lesions of uterine cervix has important practical significance.
