CAJ | 학술논문

目的：观察痰热清注射液治疗慢性支气管炎急性发作（AECB）的临床疗效。方法将62例AECB患者随机分为治疗组32例和对照组30例；治疗组采用痰热清注射液30 mL加5％葡萄糖注射液250 mL静脉滴注，对照组用盐酸氨溴索注射液60 mg加生理盐水100 mL、乳酸左氧氟沙星注射液0.4 g静脉滴注；每天1次，疗程7 d。结果治疗后两组患者临床症状均有所改善，治疗组总有效率为96.9％（31/32），对照组为93.3％（28/30）；两组比较，差异无统计学意义（χ2=0.422，P=0.516）；治疗组在咳痰消失时间、退热起效时间方面明显优于对照组，差异均有统计学意义（t=2.473、2.767，P<0.05）。结论与盐酸氨溴索联合左氧氟沙星注射液的疗效比较，痰热清注射液能快速改善AECB患者的咳痰及发热症状，疗程短且效果确切，是一种安全、有效的退热祛痰药，未发现明显不良反应。
목적：관찰담열청주사액치료만성지기관염급성발작（AECB）적림상료효。방법장62례AECB환자수궤분위치료조32례화대조조30례；치료조채용담열청주사액30 mL가5％포도당주사액250 mL정맥적주，대조조용염산안추색주사액60 mg가생리염수100 mL、유산좌양불사성주사액0.4 g정맥적주；매천1차，료정7 d。결과치료후량조환자림상증상균유소개선，치료조총유효솔위96.9％（31/32），대조조위93.3％（28/30）；량조비교，차이무통계학의의（χ2=0.422，P=0.516）；치료조재해담소실시간、퇴열기효시간방면명현우우대조조，차이균유통계학의의（t=2.473、2.767，P<0.05）。결론여염산안추색연합좌양불사성주사액적료효비교，담열청주사액능쾌속개선AECB환자적해담급발열증상，료정단차효과학절，시일충안전、유효적퇴열거담약，미발현명현불량반응。
Objective To observe the clinical efficacy of Tanreqing injection in treating acute exacerbation of chronic bronchitis(AECB). Methods A total of 62 patients with AECB were randomly divided into treatment group (n=32) and control group(n=30). The treatment group were treated with 30 mL Tanreqing injection and 250 mL 5%glucose injection for intravenous drip,while the control group were treated with 60 mg ambroxol hydrochloride injection and 100 mL normal saline+0.4 g lev-ofloxacin lactate injection for entravenous drip ,once daily. The treatment course in both groups were 7 d. Results After treat-ment,the clinical symptoms were improved in both groups,and the total effective rate was 96.9%(31/32) in the treatment group and 93.3%(28/30) in the control group with statistically significant difference(χ2=0.422,P=0.516). The treatment group was su-perior to control group remarkably on time of expectoration disappearance and fever disappearance ,the difference between the two groups had statistical significance(t=2.473,2.767,P<0.05). Conclusion Compared with the treatment of ambroxol hydrochloride combined with levofloxacin injection,Tanreqing injection can quickly improve the expectoration and fever symptoms of AECB patients with short treatment course and exact effect ,it is a safe and effective antipyretic and expectorant drug without significant side effects.