CAJ | 학술논문

采用热聚合方法,以D-萘普生(D-N p x)为模板分子,N-异丙基丙烯酰胺(NIPAAm)为功能单体, N,N’-亚甲基双丙烯酰胺(MBAA)和二甲基丙烯酸乙二醇酯(EGDMA)分别为交联剂,制备了一种温敏 D-Npx分子印迹凝胶(MIH),研究了凝胶的温敏性以及交联剂的种类和浓度对凝胶结构和分离性能等的影响。研究结果表明,随着MBAA含量的增加,MI H 的平衡溶胀率降低,且 MIH 对 D-Npx 的吸附和脱附量先增加后逐渐减少；随 EGDMA 含量的增加,MI H 对D-Npx的吸附和脱附量逐渐增大。MIH 具有明显的温敏性,MBAA 含量对凝胶的最低临界溶解温度(LCST)几乎没有影响,凝胶表现出较好的溶胀-退胀性,脱附率可达90%以上。
채용열취합방법,이D-내보생(D-N p x)위모판분자,N-이병기병희선알(NIPAAm)위공능단체, N,N’-아갑기쌍병희선알(MBAA)화이갑기병희산을이순지(EGDMA)분별위교련제,제비료일충온민 D-Npx분자인적응효(MIH),연구료응효적온민성이급교련제적충류화농도대응효결구화분리성능등적영향。연구결과표명,수착MBAA함량적증가,MI H 적평형용창솔강저,차 MIH 대 D-Npx 적흡부화탈부량선증가후축점감소；수 EGDMA 함량적증가,MI H 대D-Npx적흡부화탈부량축점증대。MIH 구유명현적온민성,MBAA 함량대응효적최저림계용해온도(LCST)궤호몰유영향,응효표현출교호적용창-퇴창성,탈부솔가체90%이상。
A novel thermo-sensitive D-naproxen (D-Npx)molecularly imprinted hydrogels (MIH)was prepared by thermal polymerization with D-Npx as the template molecule,N-isopropylacrylamide as functional mono-mer,N,N'-methylene-bis-acrylamide and ethylene glycol dimethacrylate as cross-linking agent,respectively. The thermo-sensitivity and the influences of the cross-linking agent on structure and separation performance of the hydrogels were investigated.The results showed that the equilibrium swelling ratio of MIH decreased with the increase of the concentration of MBAA,and adsorption and desorption amount of D-Npx increased firstly and then decreased.The adsorption and desorption amount of D-Npx increased continually with the increase of the concentration of EGDMA.MIHs exhibit obvious thermo-sensitivity.The concentration of MBAA had little effect on the lower critical solution temperature (LCST)of the hydrogels,and MIHs exhibited excellent reverse swelling-deswelling property,the maximum of desorption amount of D-Npx could reach up to 90%.