CAJ | 학술논문

巨噬细胞广泛参与固有免疫及适应性免疫，其表型和功能具有很大可塑性，在不同微环境中巨噬细胞可分化为经典活化（M1表型）和替代活化（M2表型），其中M2表型有免疫调节作用，参与诱导Th2反应。肿瘤微环境浸润的巨噬细胞即肿瘤相关巨噬细胞（TAMs）多具M2表型，能促进肿瘤新生血管生成、肿瘤侵袭和转移。由此可见，TAMs对胃癌的发生发展具有重要的免疫调节作用，本文就此进行综述。
거서세포엄범삼여고유면역급괄응성면역，기표형화공능구유흔대가소성，재불동미배경중거서세포가분화위경전활화（M1표형）화체대활화（M2표형），기중M2표형유면역조절작용，삼여유도Th2반응。종류미배경침윤적거서세포즉종류상관거서세포（TAMs）다구M2표형，능촉진종류신생혈관생성、종류침습화전이。유차가견，TAMs대위암적발생발전구유중요적면역조절작용，본문취차진행종술。
Macrophages are a diverse phenotype that has important functions in inherent and adaptive immunity. Macrophage ac-tivation has two distinct states of polarization:the classically activated (M1) and the alternatively activated (M2) macrophage pheno-types in different micro-environments. M2 macrophages exert an immuno-regulatory activity that is associated with the induction of Th2 responses. The macrophages can infiltrate in the tumor micro-environment, and is also known as tumor-associated macrophages (TAMs). TAMs show the M2 macrophage phenotypes that have been associated with tumor neo-vascularization, infiltration, and metas-tasis. This review aims to investigate the importance of the immuno-regulatory activity of TAM in the carcinogenesis of gastric cancers.