CAJ | 학술논문

目的探讨资癸女贞胶囊用于治疗子宫内膜过薄的不育症的临床疗效。方法111例子宫内膜过薄不孕症患者采用随机数字表法随机分为研究组59例,对照组52例。其中对照组采用雌二醇进行治疗,研究组在对照组治疗的基础上予以资癸女贞胶囊进行治疗,观察排卵日子宫内膜厚度,子宫内膜螺旋动脉血流搏动指数( pulsation index,PI)及子宫内膜螺旋动脉血流阻力指数( resistance index,RI),黄体期血清雌二醇、孕酮。结果患者服用资癸女贞胶囊后子宫内膜厚度明显增加,A型内膜比例增加,两组比较差异有统计学意义(P<0.05)。应用资癸女贞胶囊患者排卵日子宫动脉RI显著低于对照组,子宫动脉PI显著低于对照组,该中药可能降低子宫动脉PI及RI,降低子宫动脉血流阻力,增加子宫动脉血流量,进而丰富子宫内膜血供,增加子宫内膜的容受性,有利于早期胚胎的着床及发育,临床妊娠率明显提高,两组相比差异有统计学意义(P<0.05)。结论口服资癸女贞胶囊联合雌二醇应用于子宫内膜薄性不孕,可使子宫内膜血供得以丰富,子宫内膜厚度及类型也可改善,提高子宫内膜容受性,提高黄体期孕酮及雌激素浓度,改善黄体功能,从而提高临床妊娠率。
목적탐토자계녀정효낭용우치료자궁내막과박적불육증적림상료효。방법111례자궁내막과박불잉증환자채용수궤수자표법수궤분위연구조59례,대조조52례。기중대조조채용자이순진행치료,연구조재대조조치료적기출상여이자계녀정효낭진행치료,관찰배란일자궁내막후도,자궁내막라선동맥혈류박동지수( pulsation index,PI)급자궁내막라선동맥혈류조력지수( resistance index,RI),황체기혈청자이순、잉동。결과환자복용자계녀정효낭후자궁내막후도명현증가,A형내막비례증가,량조비교차이유통계학의의(P<0.05)。응용자계녀정효낭환자배란일자궁동맥RI현저저우대조조,자궁동맥PI현저저우대조조,해중약가능강저자궁동맥PI급RI,강저자궁동맥혈류조력,증가자궁동맥혈류량,진이봉부자궁내막혈공,증가자궁내막적용수성,유리우조기배태적착상급발육,림상임신솔명현제고,량조상비차이유통계학의의(P<0.05)。결론구복자계녀정효낭연합자이순응용우자궁내막박성불잉,가사자궁내막혈공득이봉부,자궁내막후도급류형야가개선,제고자궁내막용수성,제고황체기잉동급자격소농도,개선황체공능,종이제고림상임신솔。
Objective To evaluate the effectiveness of Zi Gui Nv Zhen capsule on the sterility due to thin endometrium. MethodsOne hundred and eleven sterility patients with thin endometrium were randomly divided into two groups:observation group of 59 cases and control group of 52 cases. The control group was treated with estradiol valerate. Besides the treatment given to the control group, patients of observation group were given Zi Gui Nv Zhen capsule for treatment. Endometrium thickness, endometrial spiral artery blood flow pulsation index(PI) and endometrial spiral artery blood flow resistance index (RI), luteal phase serum estradiol(E2) and progesterone ( P) of after ovulation were observed. Results Observation group proportion of type A endometrium of patients with endometrial thickness increased significantly(P<0. 05) compared with the control group. Uterus artery RI in ovulation day of patients who took Zi Gui Nv Zhen capsule was significantly lower than that of the control group(P<0. 05), and uterine artery PI was significantly lower than that of the control group(P<0. 05). The herbal medicine may reduce uterine artery PI and RI, reduce the uterine artery blood flow resistance and increase the uterine artery blood flow, thus increase blood supply of endometrium, and enhance the receptivity of endometrium. That is beneficial to early embryonic implantation and development. Clinical pregnancy rate of the observation group increased significantly compared to the control group(P<0. 05). Conclusion Taking oral Zi Gui Nv Zhen capsule and estradiol valerate treatment on daily basis can enrich the blood supply to the uterus, improve endometrial thickness and type, as well as the receptivity of endometrium;increase the luteal phase of progesterone and estrogen levels, and improve the function of corpus luteum, so as to increase the clinical pregnancy rate.