CAJ | 학술논문

目的：探讨局部晚期非小细胞肺癌（non-small cell lung carcinoma，NSCLC）放疗后发生放射性肺炎（radia-tion pneumonitis ，RP）的相关因素。方法选取85例局部晚期NSCLC患者为研究对象。所有患者均无手术切除指征，采用三维适形或调强放射治疗。单因素及多因素Logistic回归分析性别，年龄，慢性阻塞性肺疾病（COPD），肿瘤位置，分期，同期放化疗，化疗周期，放疗总剂量，MLD以及V5、V20对RP的影响。结果25例患者（29．4％）出现RP。单因素分析结果显示放疗前合并COPD、放疗前化疗周期、同期放化疗、MLD、V5、V20与放射性肺炎有关（ P＜0．05）。多因素Logistic回归分析发现放疗前合并COPD、放疗前化疗周期、同期放化疗、V20以及MLD是RP发生的独立危险因素（ P＜0．05）。结论局部晚期非小细胞肺癌放疗计划应考虑患者的临床、个体因素，设定合理的放疗参数，从而降低放射性肺炎的发生率。
목적：탐토국부만기비소세포폐암（non-small cell lung carcinoma，NSCLC）방료후발생방사성폐염（radia-tion pneumonitis ，RP）적상관인소。방법선취85례국부만기NSCLC환자위연구대상。소유환자균무수술절제지정，채용삼유괄형혹조강방사치료。단인소급다인소Logistic회귀분석성별，년령，만성조새성폐질병（COPD），종류위치，분기，동기방화료，화료주기，방료총제량，MLD이급V5、V20대RP적영향。결과25례환자（29．4％）출현RP。단인소분석결과현시방료전합병COPD、방료전화료주기、동기방화료、MLD、V5、V20여방사성폐염유관（ P＜0．05）。다인소Logistic회귀분석발현방료전합병COPD、방료전화료주기、동기방화료、V20이급MLD시RP발생적독립위험인소（ P＜0．05）。결론국부만기비소세포폐암방료계화응고필환자적림상、개체인소，설정합리적방료삼수，종이강저방사성폐염적발생솔。
Objective To analyze the related factors of radiation pneumonitis in locally advanced NSCLC patients treated with radiotherapy .Methods 85 unresectable locally advanced NSCLC patients were selected ,all the patients received three-di-mensional conformal radiation therapy (3DCRT) or intensity modulated radiation therapy ( IMRT).The relationship of radiation pneumonitis and sex,age,COPD,pathologic type,lesion location,staging,concurrent chemotherapy,chemotherapy volume,MLD, V5,V20 was analyzed by single factor analysis and multiple factors analysis .Results 25(29.4%)patients had radiation pneu-monitis(RP).Single factor analysis showed that COPD,the cycles of pre-chemotherapy,concurrent chemotherapy,MLD,V5,V20 were correlated with radiation pneumonitis .Multiple factors analysis showed that COPD , cycles of pre-chemotherapy , concurrent chemotherapy,V20 and MLD were independent risk factors for radiation pneumonitis (P<0.05).Conclusion For locally ad-vanced NSCLC patients ,clinical and individual factors should be taken into account to set a reasonable radiotherapy plan ,and it can decrease incidence rate of radiation pneumonitis .