CAJ | 학술논문

目的：探讨复方苦参注射液对原发性肺癌放射性肺炎的防治效果。方法将220例肺癌患者，随机分为两组，对照组患者仅予单纯放射治疗（6MV-XRay），观察组在其基础上联合使用复方苦参注射液，观察两组临床疗效。结果治疗后CR、PR、SD、PD观察组和对照组肺癌患者分别为34、61、12和3例和27、50、21、12例，有效率分别为86．36％对70．00％，差异有统计学意义（P＜0．05）。放射损伤0级、1级、2级、3级及以上观察组和对照组初次用药后及用药3个月后分别为50、53、7、0例和39、57、14、0例；71、36、2、1例和38、53、14、5例，差异有统计学意义（P＜0．05）。结论复方苦参注射液能够减轻原发性肺癌放疗不良反应，可以有效预防放射性肺损伤，显著改善患者的生活质量，可作为肺癌患者化疗较为理想的辅助用药。
목적：탐토복방고삼주사액대원발성폐암방사성폐염적방치효과。방법장220례폐암환자，수궤분위량조，대조조환자부여단순방사치료（6MV-XRay），관찰조재기기출상연합사용복방고삼주사액，관찰량조림상료효。결과치료후CR、PR、SD、PD관찰조화대조조폐암환자분별위34、61、12화3례화27、50、21、12례，유효솔분별위86．36％대70．00％，차이유통계학의의（P＜0．05）。방사손상0급、1급、2급、3급급이상관찰조화대조조초차용약후급용약3개월후분별위50、53、7、0례화39、57、14、0례；71、36、2、1례화38、53、14、5례，차이유통계학의의（P＜0．05）。결론복방고삼주사액능구감경원발성폐암방료불량반응，가이유효예방방사성폐손상，현저개선환자적생활질량，가작위폐암환자화료교위이상적보조용약。
Objective To investigate prevention of Fufangkushen injection on radiation pneumonitis in primary lung cancer patients.Methods 220 cases of lung cancer patients were randomly divided into 2 groups.The control group received ra-diotherapy alone (6MV-XRay),the observation group received radiotherapy and Fufangkushen injection ,clinical efficacy of the 2 groups were observed.Results After treatment,CR,PR,SD and PD of the observation group were 34 cases,61 cases,12 cases, and 3 cases,CR,PR,SD and PD of the control group were 27 cases,50 cases,21 cases,and 12 cases,effective rates of the 2 groups were 86.36%and 70.00%,respectively,difference was statistically significant (P<0.05).Patients with grade 0,1,2,3 and above radiation injury in the observation group after initial treatment and 3 months after treatment were 50 cases,53 cases,7 cases,0 case,and 39 cases,57cases,14 cases,0 case;and patients with grade 0,1,2,3 and above radiation injury in the control group after initial treatment and 3 months after treatment were 71 cases,36 cases,2 cases,1 case,and 38 cases,53cases,14 ca-ses,5 cases,the difference was statistically significant (P<0.05).Conclusion Fufangkushen injection can reduce the adverse reactions of primary lung cancer ,can effectively prevent radiation-induced lung injury and significantly improve the quality of life of patients.It is ideal adjuvant of chemotherapy for patients with lung cancer .