脑与神经疾病杂志
腦與神經疾病雜誌
뇌여신경질병잡지
JOURNAL OF BRAIN AND NERVOUS DISEASES
2014年
2期
121-124
,共4页
TIA%颈动脉粥样硬化%溶血磷脂酸%D-二聚体
TIA%頸動脈粥樣硬化%溶血燐脂痠%D-二聚體
TIA%경동맥죽양경화%용혈린지산%D-이취체
TIA%Carotid atherosclerosis%Lysophosphatidic acid%D-dimer
目的：探讨TIA患者颈动脉粥样硬化与溶血磷脂酸（ LpA）、D-二聚体（ DD）的相关性。方法选择196例TIA患者，同时选择120例健康者作为对照组。由两位B超室副主任医师进行颈动脉超声检查，观察颈动脉内膜厚度、回声强度，观察颈动脉有无斑块，斑块的部位、形状、大小及表面是否有溃疡等。结果TIA患者组的LpA、DD水平均显著高于健康者组，两者比较差异有统计学意义（P＜0．05），随着颈动脉粥样硬化的严重程度的增加，LpA、DD水平有逐渐增加的趋势；通过不同斑块性质的比较发现，各组间LpA、DD水平均P＜0．05，DD水平与斑块的稳定性有关。结论颈动脉粥样硬化的发生与LpA、DD水平相关，颈动脉粥样硬化的程度与LpA、DD水平相关，LpA、DD水平在一定程度上可反映颈动脉粥样硬化的进展情况。
目的：探討TIA患者頸動脈粥樣硬化與溶血燐脂痠（ LpA）、D-二聚體（ DD）的相關性。方法選擇196例TIA患者，同時選擇120例健康者作為對照組。由兩位B超室副主任醫師進行頸動脈超聲檢查，觀察頸動脈內膜厚度、迴聲彊度，觀察頸動脈有無斑塊，斑塊的部位、形狀、大小及錶麵是否有潰瘍等。結果TIA患者組的LpA、DD水平均顯著高于健康者組，兩者比較差異有統計學意義（P＜0．05），隨著頸動脈粥樣硬化的嚴重程度的增加，LpA、DD水平有逐漸增加的趨勢；通過不同斑塊性質的比較髮現，各組間LpA、DD水平均P＜0．05，DD水平與斑塊的穩定性有關。結論頸動脈粥樣硬化的髮生與LpA、DD水平相關，頸動脈粥樣硬化的程度與LpA、DD水平相關，LpA、DD水平在一定程度上可反映頸動脈粥樣硬化的進展情況。
목적：탐토TIA환자경동맥죽양경화여용혈린지산（ LpA）、D-이취체（ DD）적상관성。방법선택196례TIA환자，동시선택120례건강자작위대조조。유량위B초실부주임의사진행경동맥초성검사，관찰경동맥내막후도、회성강도，관찰경동맥유무반괴，반괴적부위、형상、대소급표면시부유궤양등。결과TIA환자조적LpA、DD수평균현저고우건강자조，량자비교차이유통계학의의（P＜0．05），수착경동맥죽양경화적엄중정도적증가，LpA、DD수평유축점증가적추세；통과불동반괴성질적비교발현，각조간LpA、DD수평균P＜0．05，DD수평여반괴적은정성유관。결론경동맥죽양경화적발생여LpA、DD수평상관，경동맥죽양경화적정도여LpA、DD수평상관，LpA、DD수평재일정정도상가반영경동맥죽양경화적진전정황。
Objective To explore the correlation with carotid atherosclerosis of the patients and lysophosphatidic acid, the D-dimer.Methods 196 cases of the TIA patients were choosed as TIA group , and 120 cases of healthy persons were choosed as control group .Carotid ultrasound examination was operated by the same ultrasound doctor, and observed the intima-media thickness of carotid artery and echo intensity , observed with or without plaque of carotid artery , and plaque location , shape, size and surface whether there was ulcers .Results The levels of lysophosphatidic acid, D-dimer with patients were significantly higher than the healthy group , the difference was significant(P<0.05), and accompanied by the increase in the severity of carotid atherosclerosis , its levels had a growing trend.By comparison of the different nature of plaque , the levels of lysophosphatidic acid , D-dimer among the groups were significant differences ( P<0.05) , and the levels of D-dimer levels were related with the stability of the plaque .Conclusion The levels of lysophosphatidic acid and D-dimer are related the occurrence with carotid atherosclerosis; The levels of lysophosphatidic acid and D-dimer are related the extent with carotid atherosclerosis;To a certain extent ,the levels of lysophosphatidic acid and D-dimer can reflect the progress of carotid atherosclerosis .
