CAJ | 학술논문

目的：研究KAI1和CD44 V6在胃癌中的表达和意义，探讨它们之间的关系。方法采用免疫组化技术检测61例胃癌组织和20例癌旁正常胃组织中KAI1和CD44V6的表达情况。结果胃癌组织中KAI1蛋白的阳性率显著低于癌旁正常胃组织（P＜0．05）；胃癌组织中 CD44V6蛋白的阳性率显著高于癌旁正常胃组织（P＜0．05）；KAI1、CD44V6的表达与胃癌的浆膜侵犯、临床分期、组织分化程度、淋巴结转移显著相关（P＜0．05），而与年龄、性别无关（P＞0．05）。 KAI1与CD44V6在胃癌组织中的表达呈负相关（P＜0．01）。结论 KAI1与CD44V6在胃癌的发生、发展和侵袭转移中起着相互抑制的作用，检测KAI1及CD44 V6蛋白对于判断胃癌的生物学行为具有重要的价值。
목적：연구KAI1화CD44 V6재위암중적표체화의의，탐토타문지간적관계。방법채용면역조화기술검측61례위암조직화20례암방정상위조직중KAI1화CD44V6적표체정황。결과위암조직중KAI1단백적양성솔현저저우암방정상위조직（P＜0．05）；위암조직중 CD44V6단백적양성솔현저고우암방정상위조직（P＜0．05）；KAI1、CD44V6적표체여위암적장막침범、림상분기、조직분화정도、림파결전이현저상관（P＜0．05），이여년령、성별무관（P＞0．05）。 KAI1여CD44V6재위암조직중적표체정부상관（P＜0．01）。결론 KAI1여CD44V6재위암적발생、발전화침습전이중기착상호억제적작용，검측KAI1급CD44 V6단백대우판단위암적생물학행위구유중요적개치。
Objective To study the expression of KAI1 and CD44V6 in gastric carcinoma and its clinical significance , and to investigate their relationship .Methods SP immunohistochemistry was used to detect the expression of KAI 1 and CD44V6 protein in 61 cases of gastric carcinoma tissues and 20 cases of adjacent normal gastric tissues .Results The positive rate of KAI1 in gastric carcinoma tissues was significantly lower than that of the adjacent normal gastric tissues (P<0.05) ,and the pos-itive rate of CD44V6 in gastric carcinoma tissues was significantly higher than that of the adjacent normal gastric tissues ( P<0.05).The expression of KAI1 and CD44V6 was associated with serosal invasion , the tumor stage ,grade of tumor differentia-tion,lymph node metastasis(P<0.05) while not related with age, and sex(P>0.05).KAI1 expression was negatively correla-ted with CD44V6 expression(P<0.01).Conclusion KAI1 and CD44V6 protein restrains each other in the happening、devel-opment、invasion and metastasis of gastric carcinoma ,the detection of KAI1 and CD44V6 protein is of important value in evalua-ting biological behaviors of gastric carcinoma .