实验与检验医学
實驗與檢驗醫學
실험여검험의학
EXPERIMENTAL AND LABORATORY MEDICINE
2014年
2期
112-113,141
,共3页
小而密低密度脂蛋白%冠心病%动脉硬化
小而密低密度脂蛋白%冠心病%動脈硬化
소이밀저밀도지단백%관심병%동맥경화
Coronary heart disease%Small,dense low density lipoprotein%Atherosclerosis
目的：观察冠心病(CHD)患者血清小而密低密度脂蛋白(sdLDL)的水平，探讨sdLDL与CHD的关系。方法采用2%~16%的非变性梯度胶电泳检测经冠脉造影证实的50例CHD患者sdLDL水平，用30例冠脉造影阴性者和30例健康人作为对照，观察各组间的变化，采用多元逐步回归统计分析，以了解CHD危险因素对sdLDL的影响。结果冠脉造影阳性组的血清sdLDL(56.2±11.3)%明显高于对冠照阴性(41.5±10.0)%(P<0.01)与健康对照组(40.3±9.8)%(P<0.01)；sdLDL异常组血清TG水平增高，HDL-C水平降低，均与正常组存在显著差异(P<0.01)。结论血清sdLDL测定可作为预测CHD危险性的指标。
目的：觀察冠心病(CHD)患者血清小而密低密度脂蛋白(sdLDL)的水平，探討sdLDL與CHD的關繫。方法採用2%~16%的非變性梯度膠電泳檢測經冠脈造影證實的50例CHD患者sdLDL水平，用30例冠脈造影陰性者和30例健康人作為對照，觀察各組間的變化，採用多元逐步迴歸統計分析，以瞭解CHD危險因素對sdLDL的影響。結果冠脈造影暘性組的血清sdLDL(56.2±11.3)%明顯高于對冠照陰性(41.5±10.0)%(P<0.01)與健康對照組(40.3±9.8)%(P<0.01)；sdLDL異常組血清TG水平增高，HDL-C水平降低，均與正常組存在顯著差異(P<0.01)。結論血清sdLDL測定可作為預測CHD危險性的指標。
목적：관찰관심병(CHD)환자혈청소이밀저밀도지단백(sdLDL)적수평，탐토sdLDL여CHD적관계。방법채용2%~16%적비변성제도효전영검측경관맥조영증실적50례CHD환자sdLDL수평，용30례관맥조영음성자화30례건강인작위대조，관찰각조간적변화，채용다원축보회귀통계분석，이료해CHD위험인소대sdLDL적영향。결과관맥조영양성조적혈청sdLDL(56.2±11.3)%명현고우대관조음성(41.5±10.0)%(P<0.01)여건강대조조(40.3±9.8)%(P<0.01)；sdLDL이상조혈청TG수평증고，HDL-C수평강저，균여정상조존재현저차이(P<0.01)。결론혈청sdLDL측정가작위예측CHD위험성적지표。
Objective To investigate the serum levels of small, dense low density lipoprotein (sdLDL) in patients with coronary heart disease (CHD), and the relationship of them. Methods The serum levels of sdLDL were detected by 2%-16%non-denatur-ing gradient gel electrophoresis in 50 CHD patients who were diagnosed by coronary angiography, 30 subjects with negative coro-nary angiography and 30 healthy volunteers, respectively. The impact of CHD risk factors on sdLDL was investigated by multivari-ate stepwise regression analysis as well. Results The serum levels of sdLDL in CHD group (56.2±11.3)%were higher than that in coronary angiography negative group (41.5±10.0)% and normal controls (40.3±9.8) %. Serum TG levels in high sdLDL group were significantly higher than that in normal sdLDL group (P<0.01). And HDL-C levels in high sdLDL group were significantly lower than that in normal sdLDL group (P<0.01). Conclusion sdLDL may be a new indicator and risk factor of CHD.
