CAJ | 학술논문

高危型人乳头瘤病毒（HPV）的持续感染已被证实是宫颈癌及癌前病变发生的必要但非充分原因。HPV58是高危型HPV之一，并且感染HPV58在亚洲地区极其常见。就HPV58的流行病学特点、HPV58的感染过程和致癌机制、HPV58的整合状态与致癌性等进行综述。亚洲地区妇女的宫颈病变中，HPV58阳性率很高，尤以中国突出。其中，HPV58基因变异在其感染与地理分布及恶变的过程中有重要作用。另外，HPV58的E6和E7原癌基因高表达保留了宿主细胞的复制功能，使细胞永生化，在上皮细胞转化过程中起到关键作用。并且，HPV58基因整合到宿主基因是宫颈病变恶性转化的关键步骤。因此，考虑到HPV58在中国的高分布，关于HPV58基因变异，流行病学特点，病毒整合和病毒原癌基因等方面的大样本多来源的研究是今后主要的研究方向。
고위형인유두류병독（HPV）적지속감염이피증실시궁경암급암전병변발생적필요단비충분원인。HPV58시고위형HPV지일，병차감염HPV58재아주지구겁기상견。취HPV58적류행병학특점、HPV58적감염과정화치암궤제、HPV58적정합상태여치암성등진행종술。아주지구부녀적궁경병변중，HPV58양성솔흔고，우이중국돌출。기중，HPV58기인변이재기감염여지리분포급악변적과정중유중요작용。령외，HPV58적E6화E7원암기인고표체보류료숙주세포적복제공능，사세포영생화，재상피세포전화과정중기도관건작용。병차，HPV58기인정합도숙주기인시궁경병변악성전화적관건보취。인차，고필도HPV58재중국적고분포，관우HPV58기인변이，류행병학특점，병독정합화병독원암기인등방면적대양본다래원적연구시금후주요적연구방향。
High risk human papillomavirus (HPV) plays a necessary,though insufficient,role in the development of cervical cancer. As one of the high risk HPVs ,HPV58′s infection is very common in East-South Asian area. Thus ,our review mainly focuses on the epidemiology ,carcinogenicity and viral integration of HPV58. We found out that as one of the high risk HPV types,HPV58 is rare worldwide but being found more commonly in East Asia. E6,E7 of HPV58 are the major oncoproteins,which are responsible for the transformation of host cells. Moreover,the integration of HPV58 to the host cell also plays an important role in the transformation of host cells. Thus ,a clear study is of a great significance to the research of the pathogenesis of HPV58 in cervical carcinoma and precancerous lesions and the health of Asian women. Therefore the epidemiology,carcinogenicity and viral integration of HPV58 will be the new host research hot spots.