CAJ | 학술논문

目的：探讨莪术油注射液配合常规化疗对早期卵巢癌患者生活质量的影响。方法2010年9月-2012年12月收集早期卵巢癌患者62例，均经病理组织或细胞学确诊，随机分为观察组和对照组各31例。2组患者均采用多烯紫杉醇联合顺铂治疗方案，即在化疗第1天、第8天和第15天静脉滴注多烯紫杉醇75 mg/m2；第1～3天静脉滴注顺铂30 mg/m2，21 d为1个周期；观察组在上述治疗的基础上配合应用莪术油注射液400 mg加入500 ml 0构．9％氯化钠溶液，静脉滴注，每天1次。观察2组患者的食欲、体质量及Karnofsky评分改变，并记录不良反应。结果观察组食欲增加18例（58．1％），体质量增加21例（67．8％），Karnofsky评分升高10分以上者17例（54．8％）；对照组食欲增加7例（22．6％），体质量增加7例（22．6％），Karnofsky评分升高10分以上者7例（22．6％），2组比较差异有显著意义（ P ＜0．05）。观察组胃肠道反应、骨髓抑制发生率低于对照组（58．07％vs．67．74％，19．36％ vs．29．03％），差异有统计学意义（ P ＜0．05）。结论莪术油注射液可明显减轻化疗的不良反应，提高卵巢癌患者的生活质量。
목적：탐토아술유주사액배합상규화료대조기란소암환자생활질량적영향。방법2010년9월-2012년12월수집조기란소암환자62례，균경병리조직혹세포학학진，수궤분위관찰조화대조조각31례。2조환자균채용다희자삼순연합순박치료방안，즉재화료제1천、제8천화제15천정맥적주다희자삼순75 mg/m2；제1～3천정맥적주순박30 mg/m2，21 d위1개주기；관찰조재상술치료적기출상배합응용아술유주사액400 mg가입500 ml 0구．9％록화납용액，정맥적주，매천1차。관찰2조환자적식욕、체질량급Karnofsky평분개변，병기록불량반응。결과관찰조식욕증가18례（58．1％），체질량증가21례（67．8％），Karnofsky평분승고10분이상자17례（54．8％）；대조조식욕증가7례（22．6％），체질량증가7례（22．6％），Karnofsky평분승고10분이상자7례（22．6％），2조비교차이유현저의의（ P ＜0．05）。관찰조위장도반응、골수억제발생솔저우대조조（58．07％vs．67．74％，19．36％ vs．29．03％），차이유통계학의의（ P ＜0．05）。결론아술유주사액가명현감경화료적불량반응，제고란소암환자적생활질량。
Objective To investigate the effects of zedoary turmeric oil injection combined with conventional chemo -therapy on life quality of the patients with early stage ovarian cancer .Methods 62 cases of the patients with diagnosis as early ovarian cancer by pathology or cytology methods during 2010 September to 2012 December were randomly divided into the ob-servation group and the control group .The patients in the two groups were treated with docetaxel and cisplatin regimen in chemotherapy , at the first days , eighth days and fifteenth days , intravenous infusion of docetaxel 75 mg/m2 was applied;from the first day to the third day , intravenous infusion of cisplatin 30 mg/m2 was applied , every 21 d were taken as 1 cycles.The patients in the observation group were treated with combined zedoary turmeric oil injection (400 mg in0.9%sodium chloride solution 500 ml, intravenous drip , and one time per day ) .Based on the therapy as above , the change of the body weight , ap-petite, and Karnofsky scores of the patients in the two groups were observed and the adverse reactions were recorded .Rseul ts In the observation group, the appetite of 18 cases (58.1%) increased, the weight of 21 cases (67.8%) were gained, Karnofsky scores of 17 cases had an elevation more than 10 points (54.8%); in the control group, the appetite of 7 cases (22.6%) increased, the weight of 7 cases (22.6%) were gained, Karnofsky scores of 7 cases had an elevation more than10 points (22.6%) and there was significant difference between the two groups ( P <0.05).The gastrointestinal reaction , bone marrow inhibition degrees of the patients in the observation group was lower than those of the control group (58.07% vs. 67.74%,19.36%vs.29.03%), the difference was statistically significant ( P <0.05).Conclusion Zedoary turmeric oil injection can significantly reduce the adverse reaction of chemotherapy and improve the life quality of the in patients .