CAJ | 학술논문

高氧性急性肺损伤（HALI）是临床常见危重症，尤其是在重症医学科行气管插管机械通气的病人；机体吸入高浓度氧后会产生大量活性氧（ROS）物质，而ROS常被认为是一类有害因子，可引起机体细胞凋亡等一系列改变。研究发现，通过抑制肺泡Ⅱ型上皮细胞（AEC-Ⅱ）凋亡可能减轻HALI；因此，本文就HALI与AEC-I凋亡的关系作一综述。
고양성급성폐손상（HALI）시림상상견위중증，우기시재중증의학과행기관삽관궤계통기적병인；궤체흡입고농도양후회산생대량활성양（ROS）물질，이ROS상피인위시일류유해인자，가인기궤체세포조망등일계렬개변。연구발현，통과억제폐포Ⅱ형상피세포（AEC-Ⅱ）조망가능감경HALI；인차，본문취HALI여AEC-I조망적관계작일종술。
Hyperoxia-induced acute lung injury (HALI) is a common clinical critical disease, especially in ICU patients with endotracheal intubation mechanical ventilation; inhalation of high concentration of oxygen in the body will produce a large number of reactive oxygen species (ROS), while ROS is often considered a harmful factor, can induce cell apoptosis and a series of change. The study found, through inhibition of alveolar type II epithelial cells (AEC- Ⅱ) apoptosis may reduce the HALI; therefore, in this paper, the relationship between HALI and apoptosis of AEC-II were reviewed.