CAJ | 학술논문

为评价莪术油/（麦芽糊精-Povacoat ）微囊的质量，建立了硫酸香茅醛显色测定其载药量和包封率的方法。对莪术油乙醇溶液进行波长扫描，确定508nm为最大吸收波长，显色稳定性试验表明，反应液在150min内吸光度较稳定。莪术油检测浓度在0.1992μg/mL～9.960μg/mL范围内线性关系良好（A＝0.0947C-0.0012，r＝0.9993），微囊的载药量测定和包封率测定的方法回收率分别为99.6％和99.1％。经测定，3批微囊的载药量为51.5mg/g～53.2mg/g ，包封率为88.2％～90.7％。
위평개아술유/（맥아호정-Povacoat ）미낭적질량，건립료류산향모철현색측정기재약량화포봉솔적방법。대아술유을순용액진행파장소묘，학정508nm위최대흡수파장，현색은정성시험표명，반응액재150min내흡광도교은정。아술유검측농도재0.1992μg/mL～9.960μg/mL범위내선성관계량호（A＝0.0947C-0.0012，r＝0.9993），미낭적재약량측정화포봉솔측정적방법회수솔분별위99.6％화99.1％。경측정，3비미낭적재약량위51.5mg/g～53.2mg/g ，포봉솔위88.2％～90.7％。
In order to evaluate the quality of Zedoary turmeric oil/(maltodextrin-Povacoat) microcapsules(ZTO/M-P Mcs) ,a sulfuric acid-vanillin coloration method for determination of drug loading capacity and encapsulation efficiency was developed .Wavelength scanned on the ZTO ethanol solution was determined at 508nm as the maximum absorption wavelength .Color stability tests showed that the absorbance of reac-tion solutions was stabled at 150 minutes .Absorbance and concentration of ZTO had a good linear relationship in the range of 0.199 2μg/mL~9.96μg/mL (A=0.094 7C-0.001 2 ,r=0.999 3 ) ,the average recovery of determination of drug loading capacity and encapsulation efficien-cy were 99.6% and 99.1% respectively .According to assay results of 3 batches ,drug loading was 51.5mg/g~53.2mg/g;Encapsulation effi-ciency was 88.2% ~90.7% .