CAJ | 학술논문

目的：研究生大蓟、大蓟炭主要活性成分柳穿鱼叶苷、柳穿鱼黄素在大鼠肠道内的吸收情况。方法：以吸收率和吸收速率常数为指标，通过大鼠外翻肠囊法对柳穿鱼叶苷和柳穿鱼黄素在大鼠小肠各肠段的吸收情况进行对比研究。结果：柳穿鱼叶苷在十二指肠、空肠、回肠、结肠段的吸收速度常数分别为0.5051依0.1927、0.9360依0.1872、0.7320依0.1335、0.2513依0.0276（μg·h-1·cm-2）；柳穿鱼黄素在十二指肠、空肠、回肠、结肠段的吸收速度常数分别为0.0591依0.0083、0.0933依0.0292、0.1123依0.0356、0.0294依0.0091（μg· h-1·cm-2）。柳穿鱼叶苷在整个小肠段累积吸收率明显大于柳穿鱼黄素。结论：二药的吸收均随时间延长而增多，且在空肠与回肠段吸收情况均好于其它肠段。柳穿鱼叶苷在整个小肠段的吸收情况明显优于柳穿鱼黄素。
목적：연구생대계、대계탄주요활성성분류천어협감、류천어황소재대서장도내적흡수정황。방법：이흡수솔화흡수속솔상수위지표，통과대서외번장낭법대류천어협감화류천어황소재대서소장각장단적흡수정황진행대비연구。결과：류천어협감재십이지장、공장、회장、결장단적흡수속도상수분별위0.5051의0.1927、0.9360의0.1872、0.7320의0.1335、0.2513의0.0276（μg·h-1·cm-2）；류천어황소재십이지장、공장、회장、결장단적흡수속도상수분별위0.0591의0.0083、0.0933의0.0292、0.1123의0.0356、0.0294의0.0091（μg· h-1·cm-2）。류천어협감재정개소장단루적흡수솔명현대우류천어황소。결론：이약적흡수균수시간연장이증다，차재공장여회장단흡수정황균호우기타장단。류천어협감재정개소장단적흡수정황명현우우류천어황소。
This article was aimed to study the intestinal absorption about main active ingredients of pectolinarin and pectolinarigenin in Carboned Cirsium japonicum DC. The absorption rate and absorption rate constant were taken as indicators. The intestinal absorption of pectolinarin and pectolinarigenin were compared by everted rat intestinal sac method among different parts of the small intestine. The results showed that the absorption rate constant of pectoli-narin among duodenum, jejunum, ileum and colon parts were 0.505 1 ± 0.192 7, 0.936 0 ± 0.187 2, 0.732 0 ±0.133 5, 0.251 3 ± 0.027 6 (μg·h-1·cm-2). The absorption rate constant of pectolinarigenin among the duodenum, je-junum, ileum and colon were 0.059 1 ±0.008 3, 0.093 3 ±0.029 2, 0.112 3 ± 0.035 6, 0.029 4 ± 0.009 1 (μg·h-1·cm-2). It was concluded that the absorption of both ingredients increased over time. The absorption of both ingredi-ents in the jejunum and ileum was higher than other parts of the small intestine. The absorption rate of pectolinarin in the entire small intestine was much higher than the absorption rate of pectolinarigenin.