世界科学技术-中医药现代化
世界科學技術-中醫藥現代化
세계과학기술-중의약현대화
WORLD SCIENCE AND TECHNOLOGY-MODERNIZATION OF TRADITIONAL CHINESE MEDICINE
2014年
2期
249-253
,共5页
李霞%高俊虹%赵敬军%贲卉%喻晓春%朱兵%荣培晶
李霞%高俊虹%趙敬軍%賁卉%喻曉春%硃兵%榮培晶
리하%고준홍%조경군%분훼%유효춘%주병%영배정
固定方法%心电图ST段幅值%心率%生理/病理状态
固定方法%心電圖ST段幅值%心率%生理/病理狀態
고정방법%심전도ST단폭치%심솔%생리/병리상태
Fixing method%ST-segment amplitude in ECG%heart rate%physiological / pathological states
目的:通过对比3种不同固定状态下心电图指标的变化来选择测量小鼠心电图最佳的固定方式。方法:测量小鼠在自制鼠套、胶带捆绑以及呼吸麻醉3种不同状态下心电指标ST段幅值以及心率的变化。结果:两种动物心电图ST段幅值在捆绑和麻醉状态下较安静状态(即自制鼠套固定)明显抬高(P<0.01);C57BL6小鼠心率在捆绑状态下较安静状态明显加快(P<0.05,P<0.01),而β1/β2-AR-/-小鼠在麻醉状态下较安静状态和捆绑状态均明显减慢(P<0.01)。结论:相对于捆绑和麻醉方式,利用鼠袋固定小鼠更能真实地反映其生理/病理状态,是实验研究中测量心电指标较好的固定方式。
目的:通過對比3種不同固定狀態下心電圖指標的變化來選擇測量小鼠心電圖最佳的固定方式。方法:測量小鼠在自製鼠套、膠帶捆綁以及呼吸痳醉3種不同狀態下心電指標ST段幅值以及心率的變化。結果:兩種動物心電圖ST段幅值在捆綁和痳醉狀態下較安靜狀態(即自製鼠套固定)明顯抬高(P<0.01);C57BL6小鼠心率在捆綁狀態下較安靜狀態明顯加快(P<0.05,P<0.01),而β1/β2-AR-/-小鼠在痳醉狀態下較安靜狀態和捆綁狀態均明顯減慢(P<0.01)。結論:相對于捆綁和痳醉方式,利用鼠袋固定小鼠更能真實地反映其生理/病理狀態,是實驗研究中測量心電指標較好的固定方式。
목적:통과대비3충불동고정상태하심전도지표적변화래선택측량소서심전도최가적고정방식。방법:측량소서재자제서투、효대곤방이급호흡마취3충불동상태하심전지표ST단폭치이급심솔적변화。결과:량충동물심전도ST단폭치재곤방화마취상태하교안정상태(즉자제서투고정)명현태고(P<0.01);C57BL6소서심솔재곤방상태하교안정상태명현가쾌(P<0.05,P<0.01),이β1/β2-AR-/-소서재마취상태하교안정상태화곤방상태균명현감만(P<0.01)。결론:상대우곤방화마취방식,이용서대고정소서경능진실지반영기생리/병리상태,시실험연구중측량심전지표교호적고정방식。
This study was aimed to choose the best fixing method of electrocardiogram (ECG) measurement in mice by comparison of ECG index in three different fixing ways. Changes of ST amplitude and heart rate in ECG were measured in the self-made mouse sets, tape bundling or breathing anesthesia state. The amplitudes of the ST seg-ment in C57BL6 mice and β1/β2-AR double knockout mice were elevated in tape bundling or breathing anesthesia state in comparison with that in the self-made mouse sets (all P < 0.01). The heart rate under the tape bundling state in C57BL6 mice was significantly faster than that in the self-made mouse sets (P< 0.05 or P< 0.01). And the heart rate under anesthesia in β1/β2-AR double knockout mice was significantly slower than that in tape bundling state or the self-made mouse sets (both P < 0.01). It was concluded that relative to the binding and anesthesia method, fixing mouse in the self-made mouse sets, which can more truly reflect the physiological or pathological states, is a relatively good fixing method of ECG measurement in experimental study.