CAJ | 학술논문

目的：探讨依达拉奉对胸腔镜肺叶切除术患者血清中肺表面活性蛋白A（SP-A）和动脉血气变化的影响。方法将40例行右侧肺叶切除术的肺癌患者随机分为对照组（C组）和依达拉奉组（E组）各20例。E组于诱导后切皮前给予依达拉奉1 mg/kg，30 min内滴完；C组给予等量生理盐水。两组均于切皮前即刻（T0）、单肺通气1 h（T1）和双肺通气后1 h（T2）时抽取动、静脉血，进行动脉血气分析，并测定静脉血血清SP-A的水平。结果两组单肺通气后血清SP-A水平均有明显的升高（P＜0.05）；与C组相比，E组血清SP-A水平较低（P＜0.05），动脉血气也有明显的改善。结论依达拉奉可减少肺叶切除术患者血清 SP-A 水平，在一定程度上能够减轻术中肺部的急性损伤。
목적：탐토의체랍봉대흉강경폐협절제술환자혈청중폐표면활성단백A（SP-A）화동맥혈기변화적영향。방법장40례행우측폐협절제술적폐암환자수궤분위대조조（C조）화의체랍봉조（E조）각20례。E조우유도후절피전급여의체랍봉1 mg/kg，30 min내적완；C조급여등량생리염수。량조균우절피전즉각（T0）、단폐통기1 h（T1）화쌍폐통기후1 h（T2）시추취동、정맥혈，진행동맥혈기분석，병측정정맥혈혈청SP-A적수평。결과량조단폐통기후혈청SP-A수평균유명현적승고（P＜0.05）；여C조상비，E조혈청SP-A수평교저（P＜0.05），동맥혈기야유명현적개선。결론의체랍봉가감소폐협절제술환자혈청 SP-A 수평，재일정정도상능구감경술중폐부적급성손상。
Objective To dynamically assess the implication of Edaravone in serum surfactant protein A (SP-A) concentration and the variation of arterial blood gas during one-lung ventilation (OLV). Methods Forty ASAⅠorⅡ male patients aged 45-65 yr, with body mass index 18-26 kg/m2, without other serious organic disease, undergoing right lung cancer resection, were randomly divided into two groups (n=20 each): group C (control group) and group E (Edaravone group). The patients in group E were given 1 mg/kg of Edaravone (in 100 ml normal saline), which were infused intravenously in 30 min before skin incision, group C received the same volume of normal saline.Arterial and venous blood samples were taken after the induction of Edaravone (T0), at 1 h after OLV (T1) and 1 h after two-lung ventilation (T2). The serum surfactant protein A (SP-A) concentration and the variation of arterial blood gas were determined respectively. Results Compared with T0, the levels of SP-A were increased significantly at T1 in both groups (P<0.05). In group E, the level of Sp-A was lower than that in group C at T1(P<0.05), and the variation of arterial blood gas was also improved. Conclusion Edaravone can reduce the level of SP-A and decrease the injury induced by OLV.