中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
4期
595-599
,共5页
刘树鹏%姚飞%曾健滢%汪媛%徐炯源%李家亮%陈继冰%穆峰%牛立志%徐克成
劉樹鵬%姚飛%曾健瀅%汪媛%徐炯源%李傢亮%陳繼冰%穆峰%牛立誌%徐剋成
류수붕%요비%증건형%왕원%서형원%리가량%진계빙%목봉%우립지%서극성
食管肿瘤%肿瘤转移%冷冻疗法%总生存时间
食管腫瘤%腫瘤轉移%冷凍療法%總生存時間
식관종류%종류전이%냉동요법%총생존시간
Esophageal neoplasms%Neoplasm metastasis%Cryotherapy%Overall survival
目的：对根治性手术失败后的转移性食管癌患者氩氦刀经皮冷冻治疗的疗效进行回顾性分析。方法140例转移性食管癌患者，105例患者接受氩氦刀经皮冷冻消融治疗，35例接受化疗。对所有入组患者进行随访，统计患者总体生存期，分析病理类型、治疗方案、治疗时间及治疗次数对患者总体生存期影响。结果冷冻组患者总生存时间显著长于化疗组（冷冻组：39个月；化疗组：18个月，P＝0.0006）。在冷冻组中，鳞癌患者的总生存时间长于腺癌患者总生存时间（P＝0.0435）；及时治疗患者总生存时间长于延期治疗患者（P＝0.0193）；多次治疗的患者总生存时间长于单次治疗患者（P＝0.0172）。结论对于根治性手术失败后的转移性食管癌，冷冻治疗相比化疗更具优势，及时多次冷冻治疗效果更为显著。
目的：對根治性手術失敗後的轉移性食管癌患者氬氦刀經皮冷凍治療的療效進行迴顧性分析。方法140例轉移性食管癌患者，105例患者接受氬氦刀經皮冷凍消融治療，35例接受化療。對所有入組患者進行隨訪，統計患者總體生存期，分析病理類型、治療方案、治療時間及治療次數對患者總體生存期影響。結果冷凍組患者總生存時間顯著長于化療組（冷凍組：39箇月；化療組：18箇月，P＝0.0006）。在冷凍組中，鱗癌患者的總生存時間長于腺癌患者總生存時間（P＝0.0435）；及時治療患者總生存時間長于延期治療患者（P＝0.0193）；多次治療的患者總生存時間長于單次治療患者（P＝0.0172）。結論對于根治性手術失敗後的轉移性食管癌，冷凍治療相比化療更具優勢，及時多次冷凍治療效果更為顯著。
목적：대근치성수술실패후적전이성식관암환자아양도경피냉동치료적료효진행회고성분석。방법140례전이성식관암환자，105례환자접수아양도경피냉동소융치료，35례접수화료。대소유입조환자진행수방，통계환자총체생존기，분석병리류형、치료방안、치료시간급치료차수대환자총체생존기영향。결과냉동조환자총생존시간현저장우화료조（냉동조：39개월；화료조：18개월，P＝0.0006）。재냉동조중，린암환자적총생존시간장우선암환자총생존시간（P＝0.0435）；급시치료환자총생존시간장우연기치료환자（P＝0.0193）；다차치료적환자총생존시간장우단차치료환자（P＝0.0172）。결론대우근치성수술실패후적전이성식관암，냉동치료상비화료경구우세，급시다차냉동치료효과경위현저。
Objective This study assessed cryoablation therapeutic effect in metastatic esophageal cancer(MEC) after failure of radical surgery. Methods One hundred and forty patients were enrolled in this study. Among these metastatic esophageal cancer patients, 105 patients were carried out comprehensive cryoablation in multiple metastases and 35 patients received chemotherapy. Overall survival(OS) was assessed and the relationship between OS and therapeutic protocol, pathologic type, treatment timing and number of procedures were investigated. Results The OS of patients who received comprehensive cryoablation was significantly longer than that of those who underwent chemotherapy(39 months vs. 18 months P=0.000 6). In the cryotherapy group, the OS for squamous cell carcinoma was longer than that for adenocarcinoma(P=0.043 5);the OS for timely cryoablation was longer than that for delayed cryoablation(P=0.019 3); the OS for multiple cryoablation was longer than that for single cryoablation(P=0.017 2). Conclusion Cryotherapy may have advantages over chemotherapy in the treatment of metastatic MEC, and cryoablation may be associated with a better prognosis in patients with squamous cell carcinoma, timely and multiple treatment.
