CAJ | 학술논문

目的：比较分析剂量递增靶中靶放疗（TIT）与常规放疗脊柱转移癌的治疗结果。方法：采用放射治疗90例椎体转移癌患者（病灶118处），靶中靶放疗52例（病灶63处），计划靶体积（PTV）30～40 Gy，大体靶体积（GTV）50～60 Gy，15～25次。常规放疗38例（病灶55处），PTV 30～40 Gy，10～20次。结果：两组止痛有效率分别为90．4％、81．6％，但止痛疗效无差异。近期治疗部位改善分别为31处（49．2％）、25处（45．5％），稳定状态28处（44．4％）、20处（36．3％），恶化4处（6．35％）、10处（18．1％）。1年局部控制率、生存率分别为84．7％、68．6％，49．4％、32．2％，差异均有显著性。急性不良反应主要有血液毒性，两组无统计学差异。结论：靶中靶放射治疗脊柱转移癌是一种更安全有效的局部治疗手段，具有更好的疗效和副反应少的特点。
목적：비교분석제량체증파중파방료（TIT）여상규방료척주전이암적치료결과。방법：채용방사치료90례추체전이암환자（병조118처），파중파방료52례（병조63처），계화파체적（PTV）30～40 Gy，대체파체적（GTV）50～60 Gy，15～25차。상규방료38례（병조55처），PTV 30～40 Gy，10～20차。결과：량조지통유효솔분별위90．4％、81．6％，단지통료효무차이。근기치료부위개선분별위31처（49．2％）、25처（45．5％），은정상태28처（44．4％）、20처（36．3％），악화4처（6．35％）、10처（18．1％）。1년국부공제솔、생존솔분별위84．7％、68．6％，49．4％、32．2％，차이균유현저성。급성불량반응주요유혈액독성，량조무통계학차이。결론：파중파방사치료척주전이암시일충경안전유효적국부치료수단，구유경호적료효화부반응소적특점。
Objective To analyze the result of dose-escalated radiotherapy vs conventional radiotherapy for spinal metastases. Methods Ninety patients (118 lesions) underwent radiotherapy..There were 52 patients (63 lesions) in target in target radiotherapy (TIT) receiving PTV 30~40 Gy, GTV 50~60 Gy/15~25 f. 38 patients (55 lesions) received PTV 30~40 Gy/10~20 f in the conventional radiotherapy. Results The overall responses were 90.4% and 81.6%,respectively.but no significant difference was found. There were 31 and 25 improved lesions, 28 and 20 steady lesions, 4 and 10 worsening lesions,in two goups, respectively. 1-year local control rates and survival were 84.7%vs 68.6%and 49.4%vs 32.2%, respectively. The significant differences were found in 1-year local control rates and survival. The main acute adverse reactions were mainly hematologic toxicities , no significant difference was found. Conclusion TIT for spinal metastases is a more safe and effective treatment, with better efficacy and fewer side-reactions.