CAJ | 학술논문

目的：初步探讨USPIO（羧基化三氧化二铁磁性纳米颗粒）增强MR与Gd-DTPA增强MR在动脉粥样硬化中的成像特点，比较两者对动脉粥样硬化斑块的检出率。方法：健康雄性新西兰大白兔35只，随机分为两组，实验组30只采用球囊导管损伤腹主动脉结合高脂饮食的方法建立兔动脉粥样硬化模型。对照组5只不做干预。12周后给予平扫、Gd-DTPA增强扫描、USPIO增强扫描。分别从两种对比剂增强的图像中各随机挑选97幅，与病理检查结果行对照研究，比较两者斑块的检出率。对照组任意取材对照。结果：实验组7只球囊损伤时意外死亡，2只死于喂养，1只死于实验麻醉，20只存活。对照组5只全部存活。制成172张病理切片，病理证实134个斑块组织，易损斑块72个。USPIO增强图像中经病理HE证实斑块84幅，检出率为86．6％；钆剂增强图像中HE切片证实斑块72幅，检出率为74．2％。斑块检出率比较字2＝3．96，P＝0．046。结论：USPIO增强MRA对斑块的检出率明显高于传统钆剂增强MR对斑块的检出率。 USPIO作为新型核磁对比剂对于动脉粥样硬化的检测具有明显的优越性。
목적：초보탐토USPIO（최기화삼양화이철자성납미과립）증강MR여Gd-DTPA증강MR재동맥죽양경화중적성상특점，비교량자대동맥죽양경화반괴적검출솔。방법：건강웅성신서란대백토35지，수궤분위량조，실험조30지채용구낭도관손상복주동맥결합고지음식적방법건립토동맥죽양경화모형。대조조5지불주간예。12주후급여평소、Gd-DTPA증강소묘、USPIO증강소묘。분별종량충대비제증강적도상중각수궤도선97폭，여병리검사결과행대조연구，비교량자반괴적검출솔。대조조임의취재대조。결과：실험조7지구낭손상시의외사망，2지사우위양，1지사우실험마취，20지존활。대조조5지전부존활。제성172장병리절편，병리증실134개반괴조직，역손반괴72개。USPIO증강도상중경병리HE증실반괴84폭，검출솔위86．6％；구제증강도상중HE절편증실반괴72폭，검출솔위74．2％。반괴검출솔비교자2＝3．96，P＝0．046。결론：USPIO증강MRA대반괴적검출솔명현고우전통구제증강MR대반괴적검출솔。 USPIO작위신형핵자대비제대우동맥죽양경화적검측구유명현적우월성。
Objective To investigate the imaging characteristics of USPIO-enhanced and Gd-enhanced MRI in atherosclerosis and to compare the detection rate of atherosclerotic plaque between them. Methods Thirty-five healthy male rabbits were assigned to experimental group (n=30) to establish a model of atherosclerosis by damaging aortic tunica intima with Foley′s tube in combination with a high fat diet and 5 to control group without any intervention. At week 12, USPIO-enhanced and Gd-enhanced MRI scanning were conducted to compare the signal changes of atherosclerotic plaque before and after enhancement with the 2 contrast media. Ninety seven pictures were randomly selected respectively from the pictures enhanced by the 2 contrast media to compare the detection rate plaque between them. Pthology examination was used for detection standard. For the control group , pictures were randomly selected. Results In the experimental group, 7 rabbits died of Foley′s tube damaging, 2 died of raising and 1 died of anesthesia. All 5 rabbits in control group survived. A total of 172 pathological sections were made with 134 plaques and 72 vulnerable plaques pathologically confirmed. In pictures enhanced by USPIO , 84 plaques were confirmed by HE staining with a detection rate of 86.6%. In pictures enhanced by Gd, 72 plaques were confirmed by HE staining with a detection rate of 74.2%. Detection rate of USPIO-enhanced MRI in atherosclerosis plaque was significantly higher than that of Gd-enhanced MRI (X2=3.96, P=0.046). Conclusion USPIO shows its superiority as a new contrast medium in detection of atherosclerosis plaque.