CAJ | 학술논문

目的探讨表面活性蛋白A(SP-A)对非小细胞肺癌(NSCLC)患者预后的影响及对化疗疗效的预测价值.方法 130例接受手术治疗的NSCLC患者,腺癌98例,鳞癌26例,腺鳞癌4例,大细胞癌1例,未分化癌1例.分析其临床病理资料及SP-A表达,依据患者术后化疗与否将样本分组,分析SP-A与临床病理特征间的关系;结合术后随访的生存数据,采用Cox多元回归及Kaplan-Meier法对资料进行统计学分析.结果 SP-A阳性率为67.7％ (88/130),其中腺癌阳性率为83.0％,鳞癌阳性率12.5％,SP-A的表达水平与患者的吸烟状态密切相关;SP-A对NSCLC患者预后没有明显影响;在接受以铂类为基础的化疗患者中,SP-A阳性组的生存期明显长于SP-A阴性组.结论检测肺癌SP-A表达有助于预测以铂类为基础的化疗效果.
목적 탐토표면활성단백A(SP-A)대비소세포폐암(NSCLC)환자예후적영향급대화료료효적예측개치.방법 130례접수수술치료적NSCLC환자,선암98례,린암26례,선린암4례,대세포암1례,미분화암1례.분석기림상병리자료급SP-A표체,의거환자술후화료여부장양본분조,분석SP-A여림상병리특정간적관계;결합술후수방적생존수거,채용Cox다원회귀급Kaplan-Meier법대자료진행통계학분석.결과 SP-A양성솔위67.7％ (88/130),기중선암양성솔위83.0％,린암양성솔12.5％,SP-A적표체수평여환자적흡연상태밀절상관;SP-A대NSCLC환자예후몰유명현영향;재접수이박류위기출적화료환자중,SP-A양성조적생존기명현장우SP-A음성조.결론 검측폐암SP-A표체유조우예측이박류위기출적화료효과.
Objective To evaluate the prognostic value of surfactant protein A (SP-A) in nonsmall-cell lung carcinoma (NSCLC).Methods We retrospectively reviewed the pathological results of 130 surgically resected NSCLC patients,who were followed up.The samples were divided into groups according to chemotherapy status.SP-A expression level was correlated with clinicopathological characteristics.Overall survival was estimated using Kaplan-Meier method.Results SP-A positive rate was 67.7％ (88/130).Multivariate logistic regression analysis revealed that SP-A expression was significantly reduced in heavy smokers.Univariate and multivariable Cox regression analysis demonstrated that only SP-A was the independent variable affecting survival in chemotherapy group.Positive SP-A predicted longer survival (Logrank test,P ＜ 0.01).Conclusion SP-A is a potential biomarker for predicting the effectiveness of platinum-based chemotherapy in NSCLC.